#072 Morgan Levine, PhD, on PhenoAge and the Epigenetics of Age Acceleration — can we change the pace?

FoundMyFitness

Rhonda Patrick, Ph.D. and Rhonda Patrick에서 제공하는 콘텐츠입니다. 에피소드, 그래픽, 팟캐스트 설명을 포함한 모든 팟캐스트 콘텐츠는 Rhonda Patrick, Ph.D. and Rhonda Patrick 또는 해당 팟캐스트 플랫폼 파트너가 직접 업로드하고 제공합니다. 누군가가 귀하의 허락 없이 귀하의 저작물을 사용하고 있다고 생각되는 경우 여기에 설명된 절차를 따르실 수 있습니다 https://ko.player.fm/legal.

2+ y ago 1:29:17

MP3•에피소드 홈

Morgan Levine, Ph.D., developed the phenotypic aging clock called PhenoAge and is a Founding Principal Investigator at Altos Labs, a biotech company that seeks to understand the mechanisms that drive the aging process and age-related diseases with the hope of identifying possible interventions. Additionally, Dr. Levine is an assistant professor of pathology at the Yale University School of Medicine, where her research focuses on the science of biological aging.

Dr. Levine completed a postdoctoral fellowship with previous guest Dr. Steve Horvath, a pioneer in the field of epigenetic clocks.

In this episode, Dr. Levine and I discuss:

(00:00) Introduction to Dr. Morgan Levine
(01:19) What is aging and why does it matter to scientists?
(04:45) Hallmarks of aging
(08:59) The advantage of epigenetic clocks in research
(19:05) Epigenetic age acceleration
(36:40) Are epigenetic changes in aging a cause or consequence?
(42:15) Reversing epigenetic age with interrupted reprogramming techniques
(49:27) Therapeutic plasma exchange in aging and pro-aging factors in blood
(56:01) Lifestyle factors that accelerate epigenetic age
(01:03:23) Reliability of consumer epigenetic aging tests
(01:06:12) Construct validity of epigenetic clocks
(01:12:06) Thoughts on most exciting research in aging field
(01:13:44) Dr. Levine's lifestyle habits

Get the show notes

Looking for more? Join over 300,000 people and get the latest distilled information on sleep, depression, and fasting straight to your inbox weekly: https://www.foundmyfitness.com/newsletter

Try thirty days of our FoundMyFitness premium member to get access to exclusive episodes, emails, a live Q+A with Rhonda and more: https://www.foundmyfitness.com/trial

169 에피소드