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Dr. Denise Foster에서 제공하는 콘텐츠입니다. 에피소드, 그래픽, 팟캐스트 설명을 포함한 모든 팟캐스트 콘텐츠는 Dr. Denise Foster 또는 해당 팟캐스트 플랫폼 파트너가 직접 업로드하고 제공합니다. 누군가가 귀하의 허락 없이 귀하의 저작물을 사용하고 있다고 생각되는 경우 여기에 설명된 절차를 따르실 수 있습니다 https://ko.player.fm/legal.
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Ep. 48 - The Entourage Effect is Still a Theory

1:19:00
 
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Manage episode 464098256 series 3546136
Dr. Denise Foster에서 제공하는 콘텐츠입니다. 에피소드, 그래픽, 팟캐스트 설명을 포함한 모든 팟캐스트 콘텐츠는 Dr. Denise Foster 또는 해당 팟캐스트 플랫폼 파트너가 직접 업로드하고 제공합니다. 누군가가 귀하의 허락 없이 귀하의 저작물을 사용하고 있다고 생각되는 경우 여기에 설명된 절차를 따르실 수 있습니다 https://ko.player.fm/legal.

In 1998, a group of researchers proposed a hypothesis known as the Entourage Effect, in which a multitude of the compounds found in cannabis can synergistically work together based on the fact that these effects were also seen in the synergism properties associated with our own endocannabinoids. However, after 26 years, this hypothesis has never been supported clinically, meaning that while we have a lot of proposals and a lot of research suggesting interactions, we've never actually applied it to a patient population in a real-life setting.

In this episode of Cannabis Nurse Truths, we examine this hypothesis known as the Entourage Effect, because while there is a lot of research suggesting this phenomenon is occurring, meaning that something is happening - we just don't know what it is - critics state that there is not enough evidence to support this in science. Their claim is that it is really just a marketing tool to help promote cannabis products. So which is it - an actual phenomenon that explains why cannabis compounds work together to heal the body, or is it just a gimmick to sell more weed? Bottom line; cannabis contains over 500 compounds that all have beneficial physiological effects, so does it really matter which is true?

EPISODE RESOURCES

Al-Khazaleh, A.K., Zhou, X., Bhuyan, D.J., Münch, G.W., Al-Dalabeeh, E.A., Jaye, K., & Chang, D. (2024). The neurotherapeutic arsenal in Cannabis sativa: Insights into anti-neuroinflammatory and neuroprotective activity and potential entourage effects. Molecules, 29(2), Article 2. https://doi.org/10.3390/molecules29020410

Ben-Shabat, S., Fride, E., Sheskin, T., Tamiri, T., Rhee, M.-H., Vogel, Z., Bisogno, T., De Petrocellis, L., Di Marzo, V., & Mechoulam, R. (1998). An entourage effect: Inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. European Journal of Pharmacology, 353(1), 23–31. https://doi.org/10.1016/S0014-2999(98)00392-6

Blasco-Benito, S., Seijo-Vila, M., Caro-Villalobos, M., Tundidor, I., Andradas, C., García-Taboada, E., Wade, J., Smith, S., Guzmán, M., Pérez-Gómez, E., Gordon, M., & Sánchez, C. (2018). Appraising the “entourage effect”: Antitumor action of a pure cannabinoid versus a botanical drug preparation in preclinical models of breast cancer. Biochemical Pharmacology, 157, 285–293. https://doi.org/10.1016/j.bcp.2018.06.025

Boggs, D.L., Nguyen, J.D., Morgenson, D., Taffe, M.A., & Ranganathan, M. (2018). Clinical and preclinical evidence for functional interactions of cannabidiol and Δ9-tetrahydrocannabinol. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 43(1), 142–154. https://doi.org/10.1038/npp.2017.209

Christensen, C., Rose, M., Cornett, C., & Allesø, M. (2023). Decoding the postulated entourage effect of medicinal cannabis: What it is and what it isn’t. Biomedicines, 11(8), 2323. https://doi.org/10.3390/biomedicines11082323

Cogan, P.S. (2020). The “entourage effect” or “hodge-podge hashish”: The questionable rebranding, marketing, and expectations of cannabis polypharmacy. Expert Review of Clinical Pharmacology, 13(8), 835–845. https://doi.org/10.1080/17512433.2020.1721281

Cunha, J.M., Carlini, E.A., Pereira, A.E., Ramos, O.L., Pimentel, C., Gagliardi, R., Sanvito, W.L., Lander, N., & Mechoulam, R. (1980). Chronic administration of cannabidiol to healthy volunteers and epileptic patients. Pharmacology, 21(3), 175–185. https://doi.org/10.1159/000137430

Fowler, C.J. (2003). Plant-derived, synthetic and endogenous cannabinoids as neuroprotective agents non-psychoactive cannabinoids, ‘entourage’ compounds and inhibitors of N-acyl ethanolamine breakdown as therapeutic strategies to avoid psychotropic effects. Brain Research Reviews, 18. https://pubmed.ncbi.nlm.nih.gov/12505646/

Gallily, R., Yekhtin, Z., & Hanuš, L.O. (2015). Overcoming the bell‐shaped
dose‐response of cannabidiol by using cannabis extract enriched
in cannabidiol. Pharmacology & Pharmacy, 6(02), 75–85. https://doi.org/10.4236/pp.2015.62010

Namdar, D., Anis, O., Poulin, P., & Koltai, H. (2020). Chronological review and rational and future prospects of cannabis-based drug development. Molecules, 25(20), Article 20. https://doi.org/10.3390/molecules25204821

Pamplona, F.A., da Silva, L.R., & Coan, A.C. (2018). Potential clinical benefits of CBD-rich cannabis extracts over purified CBD in treatment-resistant epilepsy: Observational data meta-analysis. Frontiers in Neurology, 9, 759. https://doi.org/10.3389/fneur.2018.00759

Russo, E.B. (2011). Taming THC: Potential cannabis synergy and phytocannabinoid-terpenoid entourage effects: Phytocannabinoid-terpenoid entourage effects. British Journal of Pharmacology, 163(7), 1344–1364. https://doi.org/10.1111/j.1476-5381.2011.01238.x

Russo, E.B. (2016). Beyond cannabis: Plants and the endocannabinoid system. Trends in Pharmacological Sciences, 37(7), 594–605. https://doi.org/10.1016/j.tips.2016.04.005

Russo, E.B. (2019). The case for the entourage effect and conventional breeding of clinical cannabis: No “strain,” no gain. Frontiers in Plant Science, 9, 1969. https://doi.org/10.3389/fpls.2018.01969

Simei, J.L.Q., Souza, J.D.R., Lisboa, J.R., Campos, A.C., Guimarães, F.S., Zuardi, A., & Crippa, J.A.S. (2024). Does the “entourage effect” in cannabinoids exist? A narrative scoping review. Cannabis and Cannabinoid Research, 9(5), 1202–1216. https://doi.org/10.1089/can.2023.0052

Spindle, T.R., Zamarripa, C.A., Russo, E., Pollak, L., Bigelow, G., Ward, A.M., Tompson, B., Sempio, C., Shokati, T., Klawitter, J., Christians, U., & Vandrey, R. (2024). Vaporized D-limonene selectively mitigates the acute anxiogenic effects of Δ9-tetrahydrocannabinol in healthy adults who intermittently use cannabis. Drug and Alcohol Dependence, 257, 111267. https://doi.org/10.1016/j.drugalcdep.2024.111267

Svendsen, K., Sharkey, K.A., & Altier, C. (2024). Non-intoxicating cannabinoids in visceral pain. Cannabis and Cannabinoid Research, 9(1), 3–11. https://doi.org/10.1089/can.2023.0113

  continue reading

51 에피소드

Artwork
icon공유
 
Manage episode 464098256 series 3546136
Dr. Denise Foster에서 제공하는 콘텐츠입니다. 에피소드, 그래픽, 팟캐스트 설명을 포함한 모든 팟캐스트 콘텐츠는 Dr. Denise Foster 또는 해당 팟캐스트 플랫폼 파트너가 직접 업로드하고 제공합니다. 누군가가 귀하의 허락 없이 귀하의 저작물을 사용하고 있다고 생각되는 경우 여기에 설명된 절차를 따르실 수 있습니다 https://ko.player.fm/legal.

In 1998, a group of researchers proposed a hypothesis known as the Entourage Effect, in which a multitude of the compounds found in cannabis can synergistically work together based on the fact that these effects were also seen in the synergism properties associated with our own endocannabinoids. However, after 26 years, this hypothesis has never been supported clinically, meaning that while we have a lot of proposals and a lot of research suggesting interactions, we've never actually applied it to a patient population in a real-life setting.

In this episode of Cannabis Nurse Truths, we examine this hypothesis known as the Entourage Effect, because while there is a lot of research suggesting this phenomenon is occurring, meaning that something is happening - we just don't know what it is - critics state that there is not enough evidence to support this in science. Their claim is that it is really just a marketing tool to help promote cannabis products. So which is it - an actual phenomenon that explains why cannabis compounds work together to heal the body, or is it just a gimmick to sell more weed? Bottom line; cannabis contains over 500 compounds that all have beneficial physiological effects, so does it really matter which is true?

EPISODE RESOURCES

Al-Khazaleh, A.K., Zhou, X., Bhuyan, D.J., Münch, G.W., Al-Dalabeeh, E.A., Jaye, K., & Chang, D. (2024). The neurotherapeutic arsenal in Cannabis sativa: Insights into anti-neuroinflammatory and neuroprotective activity and potential entourage effects. Molecules, 29(2), Article 2. https://doi.org/10.3390/molecules29020410

Ben-Shabat, S., Fride, E., Sheskin, T., Tamiri, T., Rhee, M.-H., Vogel, Z., Bisogno, T., De Petrocellis, L., Di Marzo, V., & Mechoulam, R. (1998). An entourage effect: Inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. European Journal of Pharmacology, 353(1), 23–31. https://doi.org/10.1016/S0014-2999(98)00392-6

Blasco-Benito, S., Seijo-Vila, M., Caro-Villalobos, M., Tundidor, I., Andradas, C., García-Taboada, E., Wade, J., Smith, S., Guzmán, M., Pérez-Gómez, E., Gordon, M., & Sánchez, C. (2018). Appraising the “entourage effect”: Antitumor action of a pure cannabinoid versus a botanical drug preparation in preclinical models of breast cancer. Biochemical Pharmacology, 157, 285–293. https://doi.org/10.1016/j.bcp.2018.06.025

Boggs, D.L., Nguyen, J.D., Morgenson, D., Taffe, M.A., & Ranganathan, M. (2018). Clinical and preclinical evidence for functional interactions of cannabidiol and Δ9-tetrahydrocannabinol. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 43(1), 142–154. https://doi.org/10.1038/npp.2017.209

Christensen, C., Rose, M., Cornett, C., & Allesø, M. (2023). Decoding the postulated entourage effect of medicinal cannabis: What it is and what it isn’t. Biomedicines, 11(8), 2323. https://doi.org/10.3390/biomedicines11082323

Cogan, P.S. (2020). The “entourage effect” or “hodge-podge hashish”: The questionable rebranding, marketing, and expectations of cannabis polypharmacy. Expert Review of Clinical Pharmacology, 13(8), 835–845. https://doi.org/10.1080/17512433.2020.1721281

Cunha, J.M., Carlini, E.A., Pereira, A.E., Ramos, O.L., Pimentel, C., Gagliardi, R., Sanvito, W.L., Lander, N., & Mechoulam, R. (1980). Chronic administration of cannabidiol to healthy volunteers and epileptic patients. Pharmacology, 21(3), 175–185. https://doi.org/10.1159/000137430

Fowler, C.J. (2003). Plant-derived, synthetic and endogenous cannabinoids as neuroprotective agents non-psychoactive cannabinoids, ‘entourage’ compounds and inhibitors of N-acyl ethanolamine breakdown as therapeutic strategies to avoid psychotropic effects. Brain Research Reviews, 18. https://pubmed.ncbi.nlm.nih.gov/12505646/

Gallily, R., Yekhtin, Z., & Hanuš, L.O. (2015). Overcoming the bell‐shaped
dose‐response of cannabidiol by using cannabis extract enriched
in cannabidiol. Pharmacology & Pharmacy, 6(02), 75–85. https://doi.org/10.4236/pp.2015.62010

Namdar, D., Anis, O., Poulin, P., & Koltai, H. (2020). Chronological review and rational and future prospects of cannabis-based drug development. Molecules, 25(20), Article 20. https://doi.org/10.3390/molecules25204821

Pamplona, F.A., da Silva, L.R., & Coan, A.C. (2018). Potential clinical benefits of CBD-rich cannabis extracts over purified CBD in treatment-resistant epilepsy: Observational data meta-analysis. Frontiers in Neurology, 9, 759. https://doi.org/10.3389/fneur.2018.00759

Russo, E.B. (2011). Taming THC: Potential cannabis synergy and phytocannabinoid-terpenoid entourage effects: Phytocannabinoid-terpenoid entourage effects. British Journal of Pharmacology, 163(7), 1344–1364. https://doi.org/10.1111/j.1476-5381.2011.01238.x

Russo, E.B. (2016). Beyond cannabis: Plants and the endocannabinoid system. Trends in Pharmacological Sciences, 37(7), 594–605. https://doi.org/10.1016/j.tips.2016.04.005

Russo, E.B. (2019). The case for the entourage effect and conventional breeding of clinical cannabis: No “strain,” no gain. Frontiers in Plant Science, 9, 1969. https://doi.org/10.3389/fpls.2018.01969

Simei, J.L.Q., Souza, J.D.R., Lisboa, J.R., Campos, A.C., Guimarães, F.S., Zuardi, A., & Crippa, J.A.S. (2024). Does the “entourage effect” in cannabinoids exist? A narrative scoping review. Cannabis and Cannabinoid Research, 9(5), 1202–1216. https://doi.org/10.1089/can.2023.0052

Spindle, T.R., Zamarripa, C.A., Russo, E., Pollak, L., Bigelow, G., Ward, A.M., Tompson, B., Sempio, C., Shokati, T., Klawitter, J., Christians, U., & Vandrey, R. (2024). Vaporized D-limonene selectively mitigates the acute anxiogenic effects of Δ9-tetrahydrocannabinol in healthy adults who intermittently use cannabis. Drug and Alcohol Dependence, 257, 111267. https://doi.org/10.1016/j.drugalcdep.2024.111267

Svendsen, K., Sharkey, K.A., & Altier, C. (2024). Non-intoxicating cannabinoids in visceral pain. Cannabis and Cannabinoid Research, 9(1), 3–11. https://doi.org/10.1089/can.2023.0113

  continue reading

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