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Peter Attia, MD, Peter Attia, and MD에서 제공하는 콘텐츠입니다. 에피소드, 그래픽, 팟캐스트 설명을 포함한 모든 팟캐스트 콘텐츠는 Peter Attia, MD, Peter Attia, and MD 또는 해당 팟캐스트 플랫폼 파트너가 직접 업로드하고 제공합니다. 누군가가 귀하의 허락 없이 귀하의 저작물을 사용하고 있다고 생각되는 경우 여기에 설명된 절차를 따르실 수 있습니다 https://ko.player.fm/legal.
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#286 ‒ Journal club with Andrew Huberman: the impact of light exposure on mental health and an immunotherapy breakthrough for cancer treatment

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Manage episode 396841602 series 2352826
Peter Attia, MD, Peter Attia, and MD에서 제공하는 콘텐츠입니다. 에피소드, 그래픽, 팟캐스트 설명을 포함한 모든 팟캐스트 콘텐츠는 Peter Attia, MD, Peter Attia, and MD 또는 해당 팟캐스트 플랫폼 파트너가 직접 업로드하고 제공합니다. 누군가가 귀하의 허락 없이 귀하의 저작물을 사용하고 있다고 생각되는 경우 여기에 설명된 절차를 따르실 수 있습니다 https://ko.player.fm/legal.

View the Show Notes Page for This Episode

Become a Member to Receive Exclusive Content

Sign Up to Receive Peter’s Weekly Newsletter

Andrew Huberman, professor of neurobiology at Stanford University and host of the Huberman Lab podcast, returns for another special journal club episode. Andrew introduces an observational study investigating the influence of light exposure on circadian clock regulation and its link to mental health, while Peter covers a phase III clinical trial employing immune checkpoint inhibitors for the treatment of metastatic cancer. They delve into the essential findings of their respective papers, elucidate the reasons for their enthusiasm, and tackle potential limitations and unanswered questions. Additionally, they provide valuable insights into their approaches for comprehending research studies, aiding listeners in independently navigating this process.

We discuss:

  • The intricate relationship between light exposure, circadian rhythms, and mental health [3:30];
  • The importance of low solar angle sunlight, and other types of light needed for optimal mental and physical health [12:00];
  • Promising new lightbulb technology that simulates low solar angle sunlight [17:45];
  • The significance of both darkness and the need for direct light exposure to the eyes, specifically [20:00];
  • Some tips and advice regarding optimizing light exposure, blue blockers, and effects on circadian rhythm [22:15];
  • Andrew presents a paper which suggests avoiding light at night and seeking light during the day is associated with better mental health [25:45];
  • Examining the data: the negative impact of increasing nighttime light exposure and the positive effects of daytime light exposure [34:30];
  • Statistical analysis: the importance of focusing not only on statistical significance but also clinical relevance, power analysis, error bar range, and more [45:45];
  • Takeaways from the study of daytime and nighttime light exposure [49:45];
  • The practicalities of minimizing light exposure and screen time at night, the use of sleep trackers, and overall challenge of modern, indoor lifestyles [55:15];
  • Potential limitations of the light exposure study, reverse causality, and the complex interplay of variables in epidemiological studies [1:06:00];
  • A tangent on diet soda and sugar substitutes as an example of reverse causality [1:13:15];
  • Andrew and Peter’s take on the causality vs. correlation of light exposure to mental health, the damage of circadian disruption, and the interpretation of observational data [1:17:30];
  • A primer on the immune system as background for the paper Peter chose [1:25:00];
  • Background on cancer: causes, how it evades the immune system, and the logic behind immune checkpoint inhibitor therapy [1:35:45];
  • Peter presents a paper on immune checkpoint inhibitor therapy in cancer patients [1:50:15];
  • Unpacking the results of the checkpoint inhibitor trial [1:59:45];
  • Other noteworthy observations, including the differing results between males and females [2:15:30];
  • Adverse effects resulting from treatment with an immune checkpoint inhibitor targeting CTLA-4 [2:20:00];
  • Why melanoma is especially responsive to immunotherapy, and the remarkable success story of immunotherapy for pancreatic cancer [2:25:15];
  • Why immunotherapy may be the most important hope we have for treating cancer [2:35:30];
  • Avoiding melanoma: the sunscreen debate, sunburn as the biggest risk factor, and more [2:38:45]; and
  • More.

Connect With Peter on Twitter, Instagram, Facebook and YouTube

  continue reading

352 에피소드

Artwork
icon공유
 
Manage episode 396841602 series 2352826
Peter Attia, MD, Peter Attia, and MD에서 제공하는 콘텐츠입니다. 에피소드, 그래픽, 팟캐스트 설명을 포함한 모든 팟캐스트 콘텐츠는 Peter Attia, MD, Peter Attia, and MD 또는 해당 팟캐스트 플랫폼 파트너가 직접 업로드하고 제공합니다. 누군가가 귀하의 허락 없이 귀하의 저작물을 사용하고 있다고 생각되는 경우 여기에 설명된 절차를 따르실 수 있습니다 https://ko.player.fm/legal.

View the Show Notes Page for This Episode

Become a Member to Receive Exclusive Content

Sign Up to Receive Peter’s Weekly Newsletter

Andrew Huberman, professor of neurobiology at Stanford University and host of the Huberman Lab podcast, returns for another special journal club episode. Andrew introduces an observational study investigating the influence of light exposure on circadian clock regulation and its link to mental health, while Peter covers a phase III clinical trial employing immune checkpoint inhibitors for the treatment of metastatic cancer. They delve into the essential findings of their respective papers, elucidate the reasons for their enthusiasm, and tackle potential limitations and unanswered questions. Additionally, they provide valuable insights into their approaches for comprehending research studies, aiding listeners in independently navigating this process.

We discuss:

  • The intricate relationship between light exposure, circadian rhythms, and mental health [3:30];
  • The importance of low solar angle sunlight, and other types of light needed for optimal mental and physical health [12:00];
  • Promising new lightbulb technology that simulates low solar angle sunlight [17:45];
  • The significance of both darkness and the need for direct light exposure to the eyes, specifically [20:00];
  • Some tips and advice regarding optimizing light exposure, blue blockers, and effects on circadian rhythm [22:15];
  • Andrew presents a paper which suggests avoiding light at night and seeking light during the day is associated with better mental health [25:45];
  • Examining the data: the negative impact of increasing nighttime light exposure and the positive effects of daytime light exposure [34:30];
  • Statistical analysis: the importance of focusing not only on statistical significance but also clinical relevance, power analysis, error bar range, and more [45:45];
  • Takeaways from the study of daytime and nighttime light exposure [49:45];
  • The practicalities of minimizing light exposure and screen time at night, the use of sleep trackers, and overall challenge of modern, indoor lifestyles [55:15];
  • Potential limitations of the light exposure study, reverse causality, and the complex interplay of variables in epidemiological studies [1:06:00];
  • A tangent on diet soda and sugar substitutes as an example of reverse causality [1:13:15];
  • Andrew and Peter’s take on the causality vs. correlation of light exposure to mental health, the damage of circadian disruption, and the interpretation of observational data [1:17:30];
  • A primer on the immune system as background for the paper Peter chose [1:25:00];
  • Background on cancer: causes, how it evades the immune system, and the logic behind immune checkpoint inhibitor therapy [1:35:45];
  • Peter presents a paper on immune checkpoint inhibitor therapy in cancer patients [1:50:15];
  • Unpacking the results of the checkpoint inhibitor trial [1:59:45];
  • Other noteworthy observations, including the differing results between males and females [2:15:30];
  • Adverse effects resulting from treatment with an immune checkpoint inhibitor targeting CTLA-4 [2:20:00];
  • Why melanoma is especially responsive to immunotherapy, and the remarkable success story of immunotherapy for pancreatic cancer [2:25:15];
  • Why immunotherapy may be the most important hope we have for treating cancer [2:35:30];
  • Avoiding melanoma: the sunscreen debate, sunburn as the biggest risk factor, and more [2:38:45]; and
  • More.

Connect With Peter on Twitter, Instagram, Facebook and YouTube

  continue reading

352 에피소드

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