Spilling the CAR-T on Cardiac Fibrosis

Beyond the Abstract

Beyond the Abstract에서 제공하는 콘텐츠입니다. 에피소드, 그래픽, 팟캐스트 설명을 포함한 모든 팟캐스트 콘텐츠는 Beyond the Abstract 또는 해당 팟캐스트 플랫폼 파트너가 직접 업로드하고 제공합니다. 누군가가 귀하의 허락 없이 귀하의 저작물을 사용하고 있다고 생각되는 경우 여기에 설명된 절차를 따르실 수 있습니다 https://ko.player.fm/legal.

3y ago 20:40

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Chimeric antigen receptor (CAR) T cell therapy has revolutionized cancer treatment by engineering our own immune cells to recognize and fight cancers that are resistant to treatments like radiation and chemotherapy. But can we use CAR T cells to treat other diseases too, like cardiac fibrosis? Cardiac fibrosis, or scarring of the heart, is common following heart attacks or prolonged hypertension. At some point, many patients require heart transplants. In this episode of Beyond the Abstract, Dan and Derek discuss how scientists at the University of Pennsylvania have created a new, cell-based therapy to fight against this scarring in the heart by taking a few tricks from the fields of cancer biology and immunology.

Aghajanian et al. Targeting cardiac fibrosis with engineered T cells. Nature, September 2019. DOI: 10.1038/s41586-019-1546-z. PMID: 31511695.

The information presented here is not medical advice. Please follow all guidelines from the CDC in regards to social distancing. Consult your physician on any questions regarding your personal health.

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#Science #Biology #Podcasting Education #Abstract