Ep. 14: How a Common Asian Genetic Mutation Leads to Chronic Disease, and What to Do—with Matt Quinn and Dr. Brian Kerley

Tucker Goodrich: Debugging Life

Introduction

We look at a paper enlightening what causes chronic disease, in the context of a huge population of people who suffer from the most common human mutation, to the aldehyde dehydrogenase enzyme that detoxifies both alcohol and seed oil metabolites, the ALDH2*2 mutation. We discuss how this mutation is thought to affect the people who have it through the lens of the paper at hand.

This was a difficult video for me to edit, as both Matt and Brian share their experiences with the topic we are discussing in their own families.

I thought this was excellent, and hope many others can learn from it.

Here’s this paper: “A Common East Asian-Specific ALDH2 Mutation Causes Obesity and Insulin Resistance: Therapeutic Effect of Reducing Toxic Aldehydes by ALDH2 Activation”

Preprint:

Chang, Y.-C., Lee, H.-L., Yang, W., Hsieh, M.-L., Liu, C.-C., Lee, T.-Y., Huang, J.-Y., Nong, J.-Y., Li, F.-A., Chuang, H.-L., Ding, Z.-Z., Su, W.-L., Chueh, L.-Y., Tsai, Y.-T., Chen, C.-H., Mochly-Rosen, D., & Chuang, L.-M. (2020). A Common East Asian-Specific ALDH2 Mutation Causes Obesity and Insulin Resistance: Therapeutic Effect of Reducing Toxic Aldehydes by ALDH2 Activation. https://doi.org/10.21203/rs.3.rs-104384/v1

Published:

Chang, Y.-C., Lee, H.-L., Yang, W., Hsieh, M.-L., Liu, C.-C., Lee, T.-Y., Huang, J.-Y., Nong, J.-Y., Li, F.-A., Chuang, H.-L., Ding, Z.-Z., Su, W.-L., Chueh, L.-Y., Tsai, Y.-T., Chen, C.-H., Mochly-Rosen, D., & Chuang, L.-M. (2023). A Common East-Asian ALDH2 Mutation Causes Metabolic Disorders and the Therapeutic Effect of ALDH2 Activators. Nature Communications, 14(1), Article 1. https://doi.org/10.1038/s41467-023-41570-6

Guest info

Matt Quinn

https://twitter.com/Mqsley

https://www.mquinn.online/

Biography:

TL;DR Here's what I am working on:

I run Rebel - a fund that buys distressed SAAS and turns it around - if you want to support share our apps here​

I'm in the very early stages of building/buying a regenerative farm. Our food system is beyond broken. Our healthcare system doesn't heal people. If you're interested in the thoughts behind this read this

I've built companies, bought companies and burned companies - if you're looking for pro bono advice or mentoring - tweet/DM me here

In my day job I run a product consulting team at Tanzu Labs - if you have deep pockets and need a team to teach you how to build great software that users love - connect with me here

I have failed at so so so many things - read about them here

https://www.mquinn.online/

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Co-host

Dr. Brian Kerley

https://www.seedoilrebellion.com/

https://twitter.com/SeedOilDsrspctr

Looking to fix your diet by getting rid of seed oils?

Check out the Seedy app!

https://www.seedyapp.com/

Tucker Goodrich

Substack: https://tuckergoodrich.substack.com/

Twitter: https://twitter.com/TuckerGoodrich

Youtube: https://www.youtube.com/tuckergoodrich0

Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825

Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y

Podcast: https://sites.libsyn.com/408758

Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/

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Show Notes

Previous paper:

Ghosh, S., Qi, D., An, D., Pulinilkunnil, T., Abrahani, A., Kuo, K.-H., Wambolt, R. B., Allard, M., Innis, S. M., & Rodrigues, B. (2004). Brief Episode of STZ-Induced Hyperglycemia Produces Cardiac Abnormalities in Rats Fed a Diet Rich in N-6 Pufa. American Journal of Physiology. Heart and Circulatory Physiology, 287(6), H2518-2527. https://doi.org/10.1152/ajpheart.00480.2004

Discussed in this episode:

Ep. 12 Study: What's Worse—Carbs or Seed Oils? Understanding a High-PUFA Diet—with Dr. Brian Kerley and Matt Quinn

https://tuckergoodrich.substack.com/p/ep-115-study-whats-worsecarbs-or

HNE/4-HNE in Wikipedia

https://en.wikipedia.org/wiki/4-Hydroxynonenal

Gomes, K. M. S., Campos, J. C., Bechara, L. R. G., Queliconi, B., Lima, V. M., Disatnik, M.-H., Magno, P., Chen, C.-H., Brum, P. C., Kowaltowski, A. J., Mochly-Rosen, D., & Ferreira, J. C. B. (2014). Aldehyde Dehydrogenase 2 Activation in Heart Failure Restores Mitochondrial Function and Improves Ventricular Function and Remodelling. Cardiovascular Research, 103(4), 498–508. https://doi.org/10.1093/cvr/cvu125

If you have any questions about sources for things discussed please ask in the comments.