Your Gut Can Make GLP-1, Here’s How to Turn It Back On w/ Christina O'Connor

The Trusted Pharmacist

You’ve probably heard the hype around GLP-1s, Ozempic, Wegovy, and semaglutide. They’re the “miracle drugs” that promise appetite control, blood sugar balance, and effortless weight loss. But what if the real problem isn’t a lack of synthetic GLP-1s… but a lack of your own?

According to clinical dietitian Christina O’Connor, the problem might not be a lack of medication—it could be a lack of Akkermansia muciniphila, a little-known but powerful gut microbe that helps your body in so many ways.

Here’s what most people don’t realize: GLP-1 is a hormone your gut is supposed to produce naturally. And it turns out your ability to make it depends heavily on Akkermansia.

But for many people, Akkermansia is missing, wiped out by antibiotics, ultra-processed foods, stress, or simply never passed down at birth. And when this keystone microbe disappears, it’s not just your digestion that suffers.

Your gut lining weakens, inflammation ramps up, and your body’s ability to regulate blood sugar and appetite, via GLP-1, goes offline.

In this episode, Christina O’Connor shares the real reason people may feel like their metabolism is broken. Christina explains how Akkermansia helps regulate GLP-1, strengthen the gut lining, and lower inflammation, plus why it often goes missing and how to bring it back.

Things You’ll Learn In This Episode

-GLP-1 deficient or microbiome deficient? Could low GLP-1 levels be a symptom of a missing gut microbe, not a need for medication?

-Can a microbe really compete with Ozempic? How can Akkermansia and other strains help you reduce post-meal glucose spikes and enhance satiety naturally?

-Wake up your gut’s natural GLP-1 production What foods, fibers, and polyphenols help Akkermansia thrive and support hormone balance from the inside out?

-Why most probiotics fail What’s the difference between live and pasteurized Akkermansia?

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Guest Bio

Christina O’Connor is a Clinical Dietitian and the Senior Healthcare Account Manager at Pendulum Therapeutics, where she works at the intersection of microbiome science, nutrition, and metabolic health. Her journey into gut health began in the NICU, where she saw firsthand how foundational the microbiome is from the very beginning of life. Today, she helps healthcare providers and patients understand the powerful role that keystone strains—like Akkermansia muciniphila—play in improving gut barrier integrity, supporting GLP-1 hormone production, and optimizing blood sugar control. Christina is also a mom of two budding athletes and brings a passion for translating cutting-edge science into practical strategies for lifelong health. To learn more, visit https://pendulumlife.com/.

About Your Host

Steve Hoffart is an award-winning pharmacist, entrepreneur, speaker, and podcaster. As the visionary founder of Magnolia Pharmacy, Steve saw a need for a more personal pharmacy that could make a bigger impact. Today, Steve and his team of experts deliver on that promise, working with patients and their physicians to solve medication problems and offer personalized solutions to achieve better health and wellness. As host of The Trusted Pharmacist podcast and through his combined reach of over 250,000 on social media, Steve shares actionable advice on nutrition, supplements, and wellness strategies while advocating for meaningful change in healthcare.

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