Player FM 앱으로 오프라인으로 전환하세요!
Neurovascular Dysfunction and Neuroinflammation in Alzheimer's with Ashley Carey
Manage episode 436471130 series 3557210
In this episode of Research Renaissance, host Deborah Westphal engages in an enlightening conversation with Ashley Carey, a PhD candidate and 2023 Toffler Scholar at Temple University's Lewis Katz School of Medicine. Ashley's research focuses on the neurovascular dysfunction and neuroinflammation associated with Alzheimer's disease. She shares her journey from aspiring marine biologist to neuroscience researcher, highlighting the importance of cardiovascular health in preventing Alzheimer's.
Guest Introduction: Ashley Carey
Ashley Carey is a PhD candidate and graduate research assistant in Dr. Silvia Fossati’s lab at Temple University. She is also a 2023 Toffler Scholar. Her research examines the impact of cardiovascular risk factors on Alzheimer's disease, specifically focusing on neurovascular dysfunction and neuroinflammation. Ashley's work aims to understand how conditions like hyperhomocystinemia and hypertension contribute to Alzheimer's pathology.
Key Discussion Points
Career Motivation and Journey:
- Ashley's transition from an interest in marine biology to neuroscience during undergraduate school
- The influence of Dr. Reynolds at Lafayette College in sparking her interest in research.
- Her decision to focus on Alzheimer's disease during her PhD program at Temple University.
Research Focus:
- Examining cardiovascular risk factors like hyperhomocystinemia and hypertension in Alzheimer's disease.
- Recent publication on endothelial cell dysfunction due to amyloid beta and homocysteine exposure.
- The role of cerebral endothelial cells in maintaining vascular integrity and their impact on Alzheimer's pathology.
Significant Findings:
- Additive effects of homocysteine and amyloid beta on endothelial cell dysfunction and increased permeability.
- The importance of vascular health in preventing early neuronal damage and cognitive decline.
Challenges in Alzheimer's Research:
- Difficulty in obtaining sufficient model samples due to the aging process and cardiovascular risk factors.
- Complexity of brain vasculature and overlapping pathways complicating research.
- Funding challenges and the impact of decreased NIA pay lines on dementia research.
Interdisciplinary Collaborations:
- Collaborative work with behavioral testing and biomarker studies.
- Contributions from the lymphatics department, investigating amyloid deposition in peripheral vessels.
Future Directions and Aspirations:
- Ashley’s goal to contribute to neurodegenerative disease research, possibly transitioning into a company or academia.
- The potential impact of early detection techniques and biomarker screening on Alzheimer's diagnosis and treatment.
Mentoring and Funding:
- Ashley's experience with mentorship from Dr. Fossati and its importance in her research journey.
- The role of the Toffler Scholar Grant in supporting her research and supporting career goals.
Stay tuned for more episodes of Research Renaissance by subscribing to our podcast. For further information and updates, visit our website at TofflerTrust.org. We welcome your thoughts and suggestions, so feel free to reach out!
Until then, onward and upward!
To learn more about the breakthroughs discussed in this episode and to support ongoing research, visit our website at tofflertrust.org.
Technical Podcast Support by Jon Keur at Wayfare Recording Co.
35 에피소드
Manage episode 436471130 series 3557210
In this episode of Research Renaissance, host Deborah Westphal engages in an enlightening conversation with Ashley Carey, a PhD candidate and 2023 Toffler Scholar at Temple University's Lewis Katz School of Medicine. Ashley's research focuses on the neurovascular dysfunction and neuroinflammation associated with Alzheimer's disease. She shares her journey from aspiring marine biologist to neuroscience researcher, highlighting the importance of cardiovascular health in preventing Alzheimer's.
Guest Introduction: Ashley Carey
Ashley Carey is a PhD candidate and graduate research assistant in Dr. Silvia Fossati’s lab at Temple University. She is also a 2023 Toffler Scholar. Her research examines the impact of cardiovascular risk factors on Alzheimer's disease, specifically focusing on neurovascular dysfunction and neuroinflammation. Ashley's work aims to understand how conditions like hyperhomocystinemia and hypertension contribute to Alzheimer's pathology.
Key Discussion Points
Career Motivation and Journey:
- Ashley's transition from an interest in marine biology to neuroscience during undergraduate school
- The influence of Dr. Reynolds at Lafayette College in sparking her interest in research.
- Her decision to focus on Alzheimer's disease during her PhD program at Temple University.
Research Focus:
- Examining cardiovascular risk factors like hyperhomocystinemia and hypertension in Alzheimer's disease.
- Recent publication on endothelial cell dysfunction due to amyloid beta and homocysteine exposure.
- The role of cerebral endothelial cells in maintaining vascular integrity and their impact on Alzheimer's pathology.
Significant Findings:
- Additive effects of homocysteine and amyloid beta on endothelial cell dysfunction and increased permeability.
- The importance of vascular health in preventing early neuronal damage and cognitive decline.
Challenges in Alzheimer's Research:
- Difficulty in obtaining sufficient model samples due to the aging process and cardiovascular risk factors.
- Complexity of brain vasculature and overlapping pathways complicating research.
- Funding challenges and the impact of decreased NIA pay lines on dementia research.
Interdisciplinary Collaborations:
- Collaborative work with behavioral testing and biomarker studies.
- Contributions from the lymphatics department, investigating amyloid deposition in peripheral vessels.
Future Directions and Aspirations:
- Ashley’s goal to contribute to neurodegenerative disease research, possibly transitioning into a company or academia.
- The potential impact of early detection techniques and biomarker screening on Alzheimer's diagnosis and treatment.
Mentoring and Funding:
- Ashley's experience with mentorship from Dr. Fossati and its importance in her research journey.
- The role of the Toffler Scholar Grant in supporting her research and supporting career goals.
Stay tuned for more episodes of Research Renaissance by subscribing to our podcast. For further information and updates, visit our website at TofflerTrust.org. We welcome your thoughts and suggestions, so feel free to reach out!
Until then, onward and upward!
To learn more about the breakthroughs discussed in this episode and to support ongoing research, visit our website at tofflertrust.org.
Technical Podcast Support by Jon Keur at Wayfare Recording Co.
35 에피소드
모든 에피소드
×1 Exploring Cognitive Super Aging and Brain Science with Dr. Tamar Gefen 53:41
1 Empowering Future Scientists: The SARE Program at Johns Hopkins University 52:35
1 Exploring the Future of Alzheimer's Research with Dr. Robert Vassar 57:26
1 Pioneering Drug Delivery for Neurological Diseases with Afreen Allam 46:30
1 Unraveling the Senses: Dr. Douglas Storace on the Olfactory Bulb and Brain Function 1:00:59
1 The Power of Strategic Communication in Healthcare with Anne Woodbury 54:51
1 Neurovascular Breakthroughs: Exploring Alzheimer's Treatments with Dr. Elisa Canepa 47:50
1 Neurovascular Dysfunction and Neuroinflammation in Alzheimer's with Ashley Carey 40:46
1 Innovative Collaborations in Biotech with Marissa Pettit Jones 50:24
1 The Technology Advancing Alzheimer's Research with Dr. Sudeshna Das 59:00
1 Navigating the Future of Alzheimer's Research with Dr. Bradley Hyman 53:27
1 Unlocking the Mysteries of Sleep with Dr. Alon Avidan 1:14:22
플레이어 FM에 오신것을 환영합니다!
플레이어 FM은 웹에서 고품질 팟캐스트를 검색하여 지금 바로 즐길 수 있도록 합니다. 최고의 팟캐스트 앱이며 Android, iPhone 및 웹에서도 작동합니다. 장치 간 구독 동기화를 위해 가입하세요.