49: Altering the View of MS With a Topographical Model

NeurologyLive® Mind Moments®

Welcome to the NeurologyLive Mind Moments podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice.
In this episode, we spoke with Stephen Krieger, MD, professor of neurology, Icahn School of Medicine, and staff neurologist, Corinne Goldsmith Dickinson Center for MS, Mount Sinai. Krieger discussed the development of his topographical model of MS and how it has been leveraged to this point as a clinical tool, as well as offered insight into a recently initiated effort with it that he presented at the 37th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), which was held virtually October 13-15, 2021.
More information, including the iPad app that is available, can be found here, MStopography.com.
Episode Breakdown:

• 1:15 – Background on the topographical model and its development
• 6:00 – Current utilization of the model and its insight into the MS disease course thus far
• 11:10 – The potential for the model to impact clinical care
• 13:05 – Neurology News Minute
• 15:15 – Topographical model-informed data in early MS and ECTRIMS presentation recap
• 21:10 – The need for better and improved tools to measure disease progression
• 25:00 – The future use of the topographical model of MS and closing thoughts

The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here:

• ANVS401 Demonstrates Safety, Improves Parkinson Disease Motor Function
• Gantenerumab Gets Breakthrough Designation for Alzheimer Following Significant Amyloid Reduction
• NDA Review for FT218 in Narcolepsy Still Ongoing, FDA Announces

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REFERENCES
1. Krieger SC, Cook K, De Nino S, Fletcher M. The topographical model of multiple sclerosis: A dynamic visualization of disease course. Neurol Neuroimmunol Neuroinflamm. 2016;3. doi:10.1212/NXI.0000000000000279
2. Laitman BM, Cook K, Fletcher M, Krieger SC. The topographical model of MS: Empirical evaluation of the recapitulation hypothesis. Mult Scler J Exper Transl Clin. 2018;4(4). doi:10.1177/2055217318806527