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Gabriele Saretzki: Beyond Telomeres: Telomerase in Neuroplasticity and Neurodegenerative Disorders
Manage episode 407153284 series 3558288
Mark Mattson에서 제공하는 콘텐츠입니다. 에피소드, 그래픽, 팟캐스트 설명을 포함한 모든 팟캐스트 콘텐츠는 Mark Mattson 또는 해당 팟캐스트 플랫폼 파트너가 직접 업로드하고 제공합니다. 누군가가 귀하의 허락 없이 귀하의 저작물을 사용하고 있다고 생각되는 경우 여기에 설명된 절차를 따르실 수 있습니다 https://ko.player.fm/legal.
The ends of chromosomes are called telomeres. In dividing cells a reverse transcriptase called telomerase adds a six-base DNA repeat to the telomeres thereby preventing their shortening. Telomere shortening occurs in proliferative tissues during aging and has been associated with a range of diseases. This led to the dogma that the only function of telomerase is to lengthen telomeres. In this episode Professor Gabriele Saretzki and I talk about our discoveries of non-telomeric functions of the telomerase protein in neurons including effects on gene expression mitochondria, and autophagy. We also talk about the potential of drugs that increase telomerase levels for the treatment of neurodegenerative disorders including Alzheimer’s and Parkinson’s diseases.
LINKS:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120688/pdf/NRR-17-2364.pdf
https://onlinelibrary-wiley-com.proxy1.library.jhu.edu/doi/epdf/10.1002/jnr.1073
137 에피소드
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