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David Rubinsztein: Autophagy 2.0: An Anecdote for Poisonous Proteins in Neurodegenerative Disorders
Manage episode 407153287 series 3558288
Mark Mattson에서 제공하는 콘텐츠입니다. 에피소드, 그래픽, 팟캐스트 설명을 포함한 모든 팟캐스트 콘텐츠는 Mark Mattson 또는 해당 팟캐스트 플랫폼 파트너가 직접 업로드하고 제공합니다. 누군가가 귀하의 허락 없이 귀하의 저작물을 사용하고 있다고 생각되는 경우 여기에 설명된 절차를 따르실 수 있습니다 https://ko.player.fm/legal.
Accumulation of toxic proteins in neurons that wither and die is a fundamental problem in neurodegenerative disorders - Alzheimer’s disease, Parkinson’s disease, Frontotemporal dementia, ALS, and Huntington’s disease. In this episode Professor David Rubinsztein at the University of Cambridge talks about how impaired autophagy results in the accumulation of the toxic proteins. Aging, and genetic and environmental factors may impair autophagy and thereby result in neurodegenerative disease. Neuroscientists and neurologists are developing ways to stimulate autophagy and thereby prevent the accumulation of toxic proteins.
LINKS:
Professor Rubinsztein’s lab page:
https://www.cimr.cam.ac.uk/staff/professor-david-rubinsztein-fmedsci-frs
Review on autophagy in neurodegenerative disorders:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930707/pdf/nihms-1771452.pdf
Article on removing toxic proteins in neurodegenerative disorders:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456907/pdf/nihms-1007879.pdf
Impaired autophagy and amyloid accumulation in Alzheimer’s disease:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174056/pdf/41593_2022_Article_1084.pdf
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