What’s up, Tribe, and welcome back to Good Moms Bad Choices! January was amazing, but its time to turn the page on the calendar and embrace beautiful new energy as we enter ‘The Journey of Love February.’ This month is all about the heart - join Erica and Milah to catch up and discuss what’s new in the world of motherhood, marriage, and amor! In this week’s episode, the ladies offer witty and sharp perspectives about personal growth in love, supporting your kids through their friend drama, and how to honor your true needs in a partnership. Mama Bear to the Rescue! The Good Moms discuss protective parenting and helping your kids fight their battles (8:00) Bad Choice of the Week: Help! My kids saw me in my lingerie! (20:00) My Happily Ever After: Erica and Milah discuss the prospect of marriage, dreams of becoming a housewife, and the top 5 ways to be confident in love (32:00) Yoni Mapping: Releasing Trauma and Increasing Pleasure (57:00) Its OK to fuck up, but also, what do you (really) bring to the table: The Good Moms have an honest discussion about finding accountability and growth before love (1:03:00) Watch This episode & more on YouTube! Catch up with us over at Patreon and get all our Full visual episodes, bonus content & early episode releases. Join our private Facebook group! Let us help you! Submit your advice questions, anonymous secrets or vent about motherhood anonymously! Submit your questions Connect With Us: @GoodMoms_BadChoices @TheGoodVibeRetreat @Good.GoodMedia @WatchErica @Milah_Mapp Official GMBC Music: So good feat Renee, Trip and http://www.anthemmusicenterprises.com Join us this summer in paradise at the Good Vibe Rest+Vibe Retreat in Costa Rica July 31- August 5 August 8 - August 13 See omnystudio.com/listener for privacy information.…
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Bloody Minded Crew에서 제공하는 콘텐츠입니다. 에피소드, 그래픽, 팟캐스트 설명을 포함한 모든 팟캐스트 콘텐츠는 Bloody Minded Crew 또는 해당 팟캐스트 플랫폼 파트너가 직접 업로드하고 제공합니다. 누군가가 귀하의 허락 없이 귀하의 저작물을 사용하고 있다고 생각되는 경우 여기에 설명된 절차를 따르실 수 있습니다 https://ko.player.fm/legal.
Baffled by blood? Confused by coags? Traumatised by TTP? Planning on quitting medical school because you've just finished haem block? Join the registrars of the Bloody Minded Crew as they tour the world of haematology one topic at at a time while procrastinating from their day jobs.
Your time is precious, so to maximise your return we look at each topic at a variety of levels so you can tailor your learning. Check out more at www.bloodyminded.com.au
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Bloody Minded Crew에서 제공하는 콘텐츠입니다. 에피소드, 그래픽, 팟캐스트 설명을 포함한 모든 팟캐스트 콘텐츠는 Bloody Minded Crew 또는 해당 팟캐스트 플랫폼 파트너가 직접 업로드하고 제공합니다. 누군가가 귀하의 허락 없이 귀하의 저작물을 사용하고 있다고 생각되는 경우 여기에 설명된 절차를 따르실 수 있습니다 https://ko.player.fm/legal.
Baffled by blood? Confused by coags? Traumatised by TTP? Planning on quitting medical school because you've just finished haem block? Join the registrars of the Bloody Minded Crew as they tour the world of haematology one topic at at a time while procrastinating from their day jobs.
Your time is precious, so to maximise your return we look at each topic at a variety of levels so you can tailor your learning. Check out more at www.bloodyminded.com.au
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1 Episode 47 - Blood Banking with the Best | An Interview with Dr Joe Chaffin, MD (aka BBGuy) 1:07:41
1:07:41 
나중에 재생 
나중에 재생 
리스트 
좋아요 
좋아요1:07:41
나중에 재생 나중에 재생 리스트 좋아요 좋아요Bashar was tasked with finding an expert to talk to about blood banking. He decided to cold-email the best transfusion-educator in the world who is probably responsible for hundreds if not thousands of haematology trainees understanding blood banking. Turns out he's an absolutely lovely guy who decided to spend an hour of his Monday morning chatting to us about podcasting, education, IgA deficiency and all the wonderful aspects of the blood bank. Join us for an hour with Dr Joe Chaffin MD, much more widely known as "The Blood Bank Guy". For more of Dr Chaffin's excellent work, check out www.bbguy.org & The Blood Bank Guy Essentials Podcast wherever you get your podcasts Timestamps 1:00 - Containing our excitement 3:38 - The Joe Chaffin story 8:15 - Getting into education 17:40 - Surprising moments in podcasting 22:45 - How to improve transfusion teaching 27:50 - The Blood Bank/Clinician interface 38:31 - What scares the Blood Bank Guy? 46:42 - The future of blood banking 49:53 - What to unlearn 57:19 - TA-GVH made easy 1:01:24 - Final words of wisdom Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
1 Episode 46 - A PerPLEXing Journey | Introduction to Apheresis 33:48
33:48 나중에 재생 나중에 재생 리스트 좋아요 좋아요33:48
나중에 재생 나중에 재생 리스트 좋아요 좋아요Red cells. White cells. Platelets. Plasma. Proteins. By your powers combined I am Captain… Whole Blood? Wouldn’t it be so much easier if we could work with each of these blood components individually. After all, we have to get them in a bag to donate to people. Before we swear off transfusion for the time being, join the Bloody Minded Crew as we learn the get back to basics of the apheresis machine, the concept of plasma exchange and how the magic of technology allows us to manipulate these components separately. Why keep all of your humours mixed together if you don’t have to? Hippocrates could never. Timestamps 0:55 - Our stupidest and best intro to date 3:10 - What is apheresis? 8:05 - Indications for apheresis 13:21 - Mechanism of apheresis 17:52 - Replacement fluids 19:23 - Physiology in plasma exchange 22:13 - Complications of plasma exchange 30:50 - Take home messages Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
1 Episode 45 - Much A-B-O about Nothing | Transfusing A-B-O Mismatched Transplants with Dr Eoghan Molloy 59:17
59:17 나중에 재생 나중에 재생 리스트 좋아요 좋아요59:17
나중에 재생 나중에 재생 리스트 좋아요 좋아요Join our visiting expert Dr Eoghan Molloy - Multitalented transfusion medicine specialist and consultant haematologist at Cork University Hospital to teach us how to cross the ABO Rubicon and provide transfusion support in ABO mismatched transplantation. Visit the lab and see what happens to the forward and reverse group when you're in the middle of changing groups. Brush up on your major, minor and bidirectional mismatches as the generally mismatched Bloody Minded Crew learn from a real expert again. PS Nick had his microphone set to ASMR so there are a few hiccups in the audio quality but the content was too good to miss Timestamps: 0:59 - Nick's real overseas friend 2:52 - Intro to Dr Eoghan Molloy 9:10 - ABO incompatibilities in transplant 15:19 - Graft manipulation 17:47 - Patient preparation in ABO mismatch 20:44 - Provision of blood products in transplant 32:51 - Red cell aplasia in transplant 38:16 - Passenger lymphocyte syndrome 40:37 - CMV in transplant 46:06 - Irradiated products 52:12 - Clinical case and wrap up Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
FOUR Antibodies. THREE Animals. TWO Crying Haem Registrars. ONE TEST - The MAIPA. Actually maybe more than two crying haem registrars. How many antibodies are too many antibodies to have inside a lab test? One? That’s just a DAT. Two? A mere sandwich ELISA. But the Monoclonal Antibody Immobilisation of Platelet Antigens (MAIPA) - that’s not just three but FOUR separate antibodies in the same test. If somehow you’ve made it this far thinking there wasn’t enough immunohaematology for you then it’s time to join the Bloody Minded Crew as they wrestle with the most anti-bodied of tests. Oh and we look at other platelet antibody testing too. Timestamps 00:52 - Thanksgiving in the lab 03:42 - Platelet antigens refresher 06:10 - FNAIT 10:55 - Transfusing in FNAIT 20:18 - Testing for FNAIT 26:56 - The PIFT 29:39 - The MAIPA 37:20 - Take home messages Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
1 Episode 43 - When your number’s not up | Platelet Refractoriness 46:25
46:25 나중에 재생 나중에 재생 리스트 좋아요 좋아요46:25
나중에 재생 나중에 재생 리스트 좋아요 좋아요Have you ever looked at your wallet after a big night out and seen that all your dollars have been conjugated to alloantibodies and phagocytosed by macrophages? Then you know what it’s like to transfuse a platelet refractory patient! Join us as we take a tour of platelet refractoriness and do our best to find some HLA-matched dollars for rent this week. Timestamps 00:52 - Bashar lives near a nuclear reactor 2:03 - Clinical case 5:38 - Defining platelet refractoriness 7:46 - Calculating platelet increments 12:42 - Causes of refractoriness 18:10 - Immune mechanisms of refractoriness 21:23 - HLA in detail 25:03 - HPA antigens 27:39 - Testing 31:46 - The Luminex assay 34:00 - Managing immune refractoriness 43:26 - Take home messages Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
1 Episode 42 - In The Lab: Rare Groups, Subgroups, Elutes and Fruit Loops | Advanced Blood Banking 48:41
48:41 나중에 재생 나중에 재생 리스트 좋아요 좋아요48:41
나중에 재생 나중에 재생 리스트 좋아요 좋아요Has this season been too simple? Want to up the difficulty? First of all you have issues, but second of all, welcome! It’s time to talk about all the things we don’t tell people about in the wider hospital - rare blood groups, subgroups, laboratory tips, tricks and more on this bumper In The Lab episode. Timestamps: 0:52 - How to get rich quick 3:58 - Episode overview 4:50 - The other blood groups 9:07 - Kell 11:37 - Duffy 13:54 - Kidd 16:53 - MNS 18:46 - ABO subgroups 22:28 - D variants 28:29 - Enzymes in pretransfusion testing 33:35 - Elutions 37:46 - Adsorptions 44:05 - ABO discrepancies 47:01 - Take home messages Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
What’s scarier than picking blood for one patient? Picking blood for TWO patients where one of them is inside the other (or only very recently outside). Obstetrics isn’t immune to the acronym train so join Nick, Cale and Bashar as we talk about HDFN, RhD prophylaxis and that OMG sensation that comes when looking after some of our smallest patients. Timestamps: 0:58 - Trust me this is worth it 2:30 - Episode overview 4:22 - Transfusion in pregnancy 5:52 - Kell in pregnancy 6:47 - Transfusion in neonates 9:58 - Intrauterine transfusion 11:00 - HDFN: Haemolytic Disease of the Fetus and Newborn 13:17 - Anti-D antibodies in HDFN 17:35 - Estimating FMH 20:23 - Anti-D prophylaxis 24:52 - Managing maternal alloantibodies 26:38 - Other important antibodies 31:20 - NIPT 33:00 - Episode Summary Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
1 Episode 40 - On The Wards: The Antibodies of Wrath | IVIG and Rituximab Reactions 54:00
54:00 나중에 재생 나중에 재생 리스트 좋아요 좋아요54:00
나중에 재생 나중에 재생 리스트 좋아요 좋아요IVIG & Rituximab – both involve Antibodies – and both can lead to infusion reactions that you may be called to as a junior doctor. But where do these antibodies even come from? Why are we even giving these treatments? What are you meant to do when called to review the patient? Head back to the wards, get your cheese ready and welcome back consultant haematologist Dr Alison Chandler to the pod to teach us about infusion reactions Timestamps: 0:53 - Yes, Nick is having a stroke 3:58 - Intro to IVIg and Rituximab 5:22 - What is IVIg? 6:46 - Where does IVIg come from 9:54 - Types of IVIg 13:58 - Indications for IVIg 19:17 - Administering IVIg 21:28 - Acute IVIg reactions 29:47 - Delayed IVIg reactions 32:31 - IVIg summary 33:36 - Intro to Rituximab 35:39 - Indications for Rituximab 40:45 - Rituximab Reactions 50:29 - Rituximab Summary Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
1 Episode 39 - Tweaks and Tune-Ups | A Guide to Blood Product Modifications 35:24
35:24 나중에 재생 나중에 재생 리스트 좋아요 좋아요35:24
나중에 재생 나중에 재생 리스트 좋아요 좋아요Keen to augment your blood transfusion game but confused as to when, where and why? Join the Bloody Minded boffins as we cover all the major modifications to blood products you can order. More importantly, why you should and sometimes shouldn't bother ordering them. Have a sensible conversation with your blood bank after you listen to this episode. Timestamps: 00:58 - How the blood bank actually works 04:03 - Aged Products 07:30 - Frozen Cells 10:32 - Transfusing the Bombay phenotype 12:10 - Leukodepletion 13:57 - CMV negative 19:17 - Irradiated units 19:52 - TA-GVHD 27:58 - HLA Matching 32:46 - Take home messages Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
1 Episode 38 - Infinity Products | Massive Transfusion Protocols 37:59
37:59 나중에 재생 나중에 재생 리스트 좋아요 좋아요37:59
나중에 재생 나중에 재생 리스트 좋아요 좋아요Perfectly balanced, as all things should be. All that blood doesn’t just arrive when you snap your fingers together. The REALITY is you need the TIME and SPACE to thaw that frozen plasma and the strength of MIND to keep all the components in the right ratios. Only the chosen few with the POWER of transfusion medicine and the SOUL of the laboratory can direct the most immense of transfusions - the massive transfusion. Listen to this episode and maybe you can run the GAUNTLET of the MTP. Timestamps: 0:53 - Get ready for MASSIVE. TRANSFUSION. PROTOCOL. 1:45 - What is an MTP? 4:10 - A bleedy example 7:11 - Activating the MTP 8:52 - Consent in MTPs 11:16 - MTP packs 12:27 - Crossing plasma groups 15:30 - 1:1:1 Transfusion 17:29 - Whole Blood Transfusion 19:49 - Acidosis 22:21 - Hypothermia 23:14 - Hypocalcaemia 25:12 - Resus Associated Coagulopathy 25:49 - DIC 26:58 - Trauma Induced Coagulopathy 29:19 - Summary of Resuscitative Endpoints 31:05 - Viscoelastic testing 33:12 - Factor Concentrates 34:55 - Take home messages Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
1 Episode 37 - In The Lab: Red Cell Matchmaking | Group and Hold, Antibody Screen, Crossmatch 32:56
32:56 나중에 재생 나중에 재생 리스트 좋아요 좋아요32:56
나중에 재생 나중에 재생 리스트 좋아요 좋아요It’s an early trip to the lab this season to explore exactly how we safely match the blood in the bank to the patient on the ward. Follow your trusty hand-labelled group-and-hold tube as we unpack what actually goes into blood grouping, antibody screening and the final hurdle, the crossmatch! Timestamps 0:52 - Nick lives in squalor, surprising nobody 2:56 - The Group 4:22 - The Forward Group 6:53 - The Reverse Group 10:55 - The Antibody Screen 18:12 - DAT vs IAT 20:39 - The Crossmatch 25:08 - Anamnestic Antibody Responses 27:58 - Phenotyping 30:25 - Episode Summary Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
1 Episode 36 - What’s in the bag, Somerset, what’s in the bag? | Blood Products 40:28
40:28 나중에 재생 나중에 재생 리스트 좋아요 좋아요40:28
나중에 재생 나중에 재생 리스트 좋아요 좋아요We’re back again to answer all of your questions- what’s exactly is a "unit" of blood and how do we go about giving it? What on earth is the difference between FFP and ELP and cryodepleted plasma? And what do each of them sound like, if you were to interpret them via a completely unnecessary collection of household objects? As always, we’ve got you covered. Timestamps: 00:55 - Bashar's special presentation 03:42 - Where do we get blood from? 05:53 - Packed Red Blood Cells (PRBC) 08:20 - When and how to transfuse PRBC 11:07 - Clerical checks 13:02 - Platelets 18:12 - Plasma products 18:32 - Fresh Frozen Plasma (FFP) 20:00 - FFP vs ELP 24:00 - Cryodepleted plasma 25:10 - Cryoprecipitate 27:24 - Albumin 28:15 - Fractionated clotting factors 29:07 - Immunoglobulins 31:12 - Leukocyte tranfusion 34:57 - Reducing transfusion-transmitted infection 38:00 - Take home messages Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
1 Episode 35 - The Other Resus | Introduction to Blood Groups 49:57
49:57 나중에 재생 나중에 재생 리스트 좋아요 좋아요49:57
나중에 재생 나중에 재생 리스트 좋아요 좋아요We’ve been out of line with the rest of #FOAM #MedEd podcasts for the longest time. Forget that haematology stuff, it’s time to talk about RESUS. Break out your adrenaline, it’s time to crack some chests and… wait what? You meant Rhesus ? With an H? Oh right… okay. Put down those trauma shears as the only thing we’ll be cracking open are the ISBT Red Cell Immunogenetics guidelines. Join the Bloody Minded Crew take you though the basics of blood grouping with a focus on ABO and Rhesus. Timestamps: 0:56 - Cale needs help with the target 3:00 - Intro to blood groups 6:02 - What is a "blood group?" 8:40 - Historical diversion on blood groups! 9:47 - Cale speaks flawless German 13:49 - The ABO group: the hatted and the hatless 18:12 - The Bombay phenotype! No hat, no hair. 20:38 - ABO frequencies 21:11 - ABO compatibilities 21:49 - Interesting (to us) ABO tidbits 24:43 - Intro to Rhesus 29:13 - Nomenclature - RhD, C, c, E, e 36:27 - Wiener classification (brace yourself) 46:27 - Take home messages Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
1 Episode 34 - On the Wards: I would do anything for blood – but I won’t do that | Transfusion Reactions 1:02:08
1:02:08 나중에 재생 나중에 재생 리스트 좋아요 좋아요1:02:08
나중에 재생 나중에 재생 리스트 좋아요 좋아요Do you fear – The Power of Blood? Have you been warned – You can’t Hurry Blood? Today we tackle all the ways Blood (and love) can go wrong. . . and how to manage it on the wards. Too cryptic? Join Bloody Minded's own consultant haematologist Dr Alison Chandler and the rest of the Bloody Minded Crew as we cover the many and varied reactions patients can have when you try and fix that haemoglobin level on the ward. Timestamps 00:53 - 3-4 nerds chatting about nonsense 03:37 - Your first transfusion reaction 05:08 - What is a transfusion reaction? 5:52 - Categorising transfusion reactions 7:26 - Acute febrile reactions 17:20 - Summary of acute febrile reactions 17:45 - Acute non-febrile transfusion reactions 22:11 - Workup and management of an acute reaction 37:44 - Delayed febrile reactions 50:08 - Delayed non-febrile reactions 53:46 - Summaries Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
1 Episode 33 - CAR-T and Chromothripsis | Multiple Myeloma Review with Dr Christian Bryant 1:02:02
1:02:02 나중에 재생 나중에 재생 리스트 좋아요 좋아요1:02:02
나중에 재생 나중에 재생 리스트 좋아요 좋아요Myeloma beware, it's time to bring out the big guns. We are incredibly thankful to be joined by a peak predator of plasma cells, Dr. Christian Bryant. He is a consultant Haematologist at RPA in Sydney, has a PhD on the immunology of myeloma and is driven by a passion to improve the treatment and understanding of all things myeloma. TIMESTAMPS 2:18 - Intro to Christian Bryant 3:05 - Why Haematology? 5:31 - Why (oh god why) myeloma? 7:28 - Heavy metal, heavy chains 9:28 - Chromothripsis - The Cause That Breaks The Camel's Back? 13:45 - In praise of plasma cells 18:38 - Genomics to risk-stratify precursor states - should we bother? 20:32 - Predicting response and high risk disease 21:43 - IMS Criteria - High Genomic Risk 28:22 - Response Kinetics - When are you nervous? 31:31 - Balancing maintenance Len vs. secondary malignancies 39:34 - Other agents for maintenance? 44:44 - CAR-T - A New Hope? 49:10 - T cell exhaustion 50:21 - What are the CAR-T target molecules for MM? 53:27 - Any hope for a cure? 57:35 - MRD Matters Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
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Bloody Minded
1 Episode 32 - Phagocytose. Pray. Love. | Haemophagocytic Lymphohistiocytosis (HLH) 41:19
41:19 나중에 재생 나중에 재생 리스트 좋아요 좋아요41:19
나중에 재생 나중에 재생 리스트 좋아요 좋아요Ferritin keeps climbing and you’re getting jumpy? Did you consult Haem and then they were bedside 5 minutes later? Ever had to donate your own blood to test the patient for something? Join Nick, Cale and Bashar as we unpack a very special bonus episode on another deadly TLA, HLH. TIMESTAMPS 3:24 - History of HLH 5:26 - What is a histiocyte? 7:44 - How do you turn *off* an immune response? 8:52 - HLH - A Definition 10:49 - What are NK cells? 13:03 - Primary HLH - "HLH Disease" 13:34 - Secondary HLH - "HLH Syndrome" 14:46 - Causes of familial HLH 16:34 - Infective causes 18:05 - Malignant causes 20:24 - Clinical presentation and diagnostic criteria 32:47 - H-Score 34:36 - Treatment - Replacing Your Dodgy Off Switch 38:04 - Prognosis 38:55 - Take Home Messages Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
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Bloody Minded
1 Episode 31 - Advanced Myeloma Nursing with A/Prof Tracy King 54:25
54:25 나중에 재생 나중에 재생 리스트 좋아요 좋아요54:25
나중에 재생 나중에 재생 리스트 좋아요 좋아요Thankfully, it's time for an actual expert to join us again on Bloody Minded! We are thrilled to be sitting down and chatting with A/Prof. Tracy King , Myeloma CNC from RPA Hospital in Sydney, Co-Founder and past president of the HSANZ Nursing Group. From convenient treatment schedulers to the side effects we should be thinking more about to many ideas to improve clinical practice, this is a veritable hour of power worth diving into. TIMESTAMPS 2:23 - Intro to Tracy King 3:30 - A Nightingale Sang in Hammersmith Square 5:22 - How did you get into myeloma nursing? 9:35 - If not nursing, what? 10:50 - What is a CNC? 14:12 - Nursing expertise in myeloma - best supportive care 16:57 - The most asked questions 19:54 - Strategies to manage complex regimens 23:13 - MyeTxScheduler - A Godsend 26:37 - What do we miss, what should we be asking more? 28:21 - The crux of communication issues 29:33 - "What matters to you today" 29:49 - Patient advocacy groups 32:04 - Steroid side effects - there's just so much dex... 35:37 - M protein variations - how to see the forest for the trees 38:22 - Time toxicity 45:44 - Quality of life assessment tools 49:35 - How to get started in advocacy/education/further work? 51:57 - Organisations - find your tribe Also we promised to link MyeTx here so have at it https://rego.interact.technology/myetx/#/main Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
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Bloody Minded
1 Episode 30 - Schnitzler’s List | Other Paraprotein Associated Diagnoses 36:18
36:18 나중에 재생 나중에 재생 리스트 좋아요 좋아요36:18
나중에 재생 나중에 재생 리스트 좋아요 좋아요All that glitters isn’t gold, and all that paraproteins isn’t myeloma. But if we’re not going to blame myeloma, then what else might be responsible? Hold on to your M-Spikes as we the Bloody Minded Team dive into the weird and wonderful world of paraproteins causing havoc in patients without myeloma. This episode isn’t for the faint of blood so get ready for an advanced look at paraproteins and take a bit of the U out of MGUS. 2:12 - The Problem with "Unknown" Significance 8:45 - Waldenström's macroglobulinemia/Lymphoplasmacytic Lymphoma 11:17 - Marginal zone lymphoma 12:42 - Cold Agglutinin Disease 15:09 - Heavy chain disease 16:27 - POEMS Syndrome 23:10 - Other Paraproteinemic Neuropathies 25:55 - TEMPI 27:03 - CANOMAD 29:16 - Schnitzler Syndrome 31:34 - Scleromyxedema 34:06 - The “paraprotein AND...” approach Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
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Bloody Minded
1 Episode 29 - On The Wards: It's Getting Hot in Here | Febrile Neutropenia 54:13
54:13 나중에 재생 나중에 재생 리스트 좋아요 좋아요54:13
나중에 재생 나중에 재생 리스트 좋아요 좋아요Its time to hit the hot girl summer of haematology (we're in Australia after all) but also the hot boy winter and Autumn and Spring. Because our patients are hot all year round and sadly all night shift and possibly all throughout your ward round. Welcome to our next On The Wards episode looking at fevers in the haematology patient with a focus on the management of febrile neutropenia. There's a lot to cover in this jumbo sized episode and we're super happy that Dr Alison Chandler agreed to return after last time. Timestamps 2:08 - Episode Overview 4:47 - What is Febrile Neutropenia? 8:59 - Reminder: What are neutrophils 13:08 - Where did the neutrophils go? 18:24 - Why is FN a big deal? 20:00 - Assessing the neutropenic patient 30:15 - Antibiotics: Get them in 33:29 - Bugs: What grows? 36:15 - That fever isn't going away 41:01 - After the fever 42:24 - Can we make the neutrophils go up? 48:00 - Prophylaxis 52:50 - Summary Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
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Bloody Minded
1 Episode 28 - In the Lab: Flow Cytometry, Mass Spectrometry & Cytogenetics in MM 42:26
42:26 나중에 재생 나중에 재생 리스트 좋아요 좋아요42:26
나중에 재생 나중에 재생 리스트 좋아요 좋아요Can’t get enough of obscure haematological lab chat, can you? Well we’ve got good news for you! Join us today as we delve even deeper into the arcane depths of flow cytometry, mass spectrometry and cytogenetics as they apply to myeloma. We promise we didn’t just make these words up. 02:23 - Flow cytometry: overview 04:01 - The flow cytometer: practical aspects 09:01 - How we interpret flow 11:44 - Myeloma flow markers 14:32 - Quality in flow 21:26 - Mass spectrometry 25:59 - Cytogenetics 27:46 - Cytogenetics assay principles 30:30 - Karyotype abnormalities 31:44 - FISH and SNP arrays 33:05 - Cytogenetics and prognostication in MM 39:59 - Take home points Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
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Bloody Minded
1 Episode 27 - In The Lab: Electrophoresis, Immunoelectrophoresis and Serum Free Light Chain Assays 48:14
48:14 나중에 재생 나중에 재생 리스트 좋아요 좋아요48:14
나중에 재생 나중에 재생 리스트 좋아요 좋아요Thought you were free of myeloma acronyms? Don’t be ridiculous - this is the haematology lab! We were born in the acronyms, moulded by them. We didn’t see a complete word until advanced training and even then it was nothing but BLINDING. Your lab tests betray you because they belong to us… but in this episode we’ll let you in on some secrets. Join Nick, Cale and Bashar in the haematology (and closely adjacent immunology) lab as they chat about just how we do that electrophoresis, why an iEPG is different to an EPG and just how useful Bence-Jones proteins are(n’t). Timestamps 3:15 - Bone marrows - not as bad as they sound? 4:25 - What even do we do with the marrow? 10:57 - Eponymous plasma cells with weird morphology 13:04 - EPG - Electrophoresis 22:23 - IEPG - Immunoelectrophoresis 29:09 - What's the deal with Bence Jones proteins 33:27 - SFLC Measurements 37:07 - The Hook/Prozone Effect 40:55 - Light chain measurement in renal dysfunction 44:32 - Take Home Messages Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
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Bloody Minded
MGUS and Myeloma too simple for your tastes? Do you like vague presentations and biopsying many tissues in a sometimes wild goose chase? Why does Congo have all the birefringent apples? Go ' AA aah ' as we TTR y to unpack AL l the problems that come with that most protean of disease - Systemic Amyloidosis! Timestamps 3:04 - Pathophysiology of Amyloid 6:52 - All The Subtypes of Amyloid 7:56 - AA Amyloid 10:08 - ABeta2M Amyloid 11:04 - Age-Related Amyloidosis = wtATTR = WTTA = SSA 14:38 - AL Amyloidosis 16:24 - Diagnosis of Amyloid 22:25 - Clinical Presentation of Amyloid 27:10 - Prognosis 32:17 - Take Home Messages Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
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Bloody Minded
1 Episode 25 - Alphabet Soup | Overview of Myeloma Treatments 47:20
47:20 나중에 재생 나중에 재생 리스트 좋아요 좋아요47:20
나중에 재생 나중에 재생 리스트 좋아요 좋아요RVd, KTd, CyBorD, DVd, EloRd - Looks like the cat got on the keyboard. Oh wait, this is just the myeloma regimens in day therapy today. Come on a journey as we attempt (mostly successfully) to avoid drug trade names! Let go of your proteasome inhibitions, phenotype your red cells and let us modulate your understanding of what it is to treat myeloma with an alphabet soups worth of drugs. We sincerely apologise to our endocrinology colleagues for how much dexamethasone we use in this episode but also generally. Timestamps 4:00 - Overview of the treatment journey 9:49 - Steroids - not the bulking kind 13:54 - Immunomodulators - the IMiDs 19:46 - Proteasome inhibitors - Bortezomib, Carflizomib 24:45 - Monoclonal antibodies - Daratumumab, Elotuzumab 28:31 - SINE Inhibitor - Selinexor 29:27 - Antibody-drug conjugates - Belantamab mafodotin 30:27 - CELMoDs - Iberdomide, mezigdomide 31:06 - Standard chemotherapy 33:15 - Autologous stem cell transplant 38:21 - T-cell directed therapy - BiTes, CAR-T 40:57 - Supportive care Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
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Bloody Minded
1 Episode 24 - Blue Fried Eggs | Intro to Multiple Myeloma 28:35
28:35 나중에 재생 나중에 재생 리스트 좋아요 좋아요28:35
나중에 재생 나중에 재생 리스트 좋아요 좋아요== I do not like blue eggs and ham, I do not like them, Sam I Am. They crowd and clump, they grow too fast, Causing troubles that can last. They make my bones feel weak and sore, And through my kidneys they gnaw! I do not like blue eggs, you see, They're signs of something wrong with me. == Timestamps 3:35 - Recap of MGUS + smouldering myeloma 4:42 - Clinical case - Mr. Peter Rotein 8:15 - What is rouleaux? 10:30 - Bone marrow biopsies - what, how, how much ow? 15:29 - Multiple myeloma 16:41 - CRAB Criteria 18:26 - SLiM Criteria 19:24 - Clinical presentations of myeloma 21:48 - Plasmacytomas 22:56 - Causes of myeloma? 24:45 - Prognosis Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
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Bloody Minded
1 Episode 23 - Help I found a paraprotein | MGUS + The Spectrum of Plasma Cell Dyscrasias 31:48
31:48 나중에 재생 나중에 재생 리스트 좋아요 좋아요31:48
나중에 재생 나중에 재생 리스트 좋아요 좋아요Ordered something you shouldn’t have and accidentally found a paraprotein again? Shame on you, but now you have to do something with it. Maybe you were genuinely suspicious for myeloma. If incidentally discovered lab findings are leaving you smouldering, this is the episode for you! Join Nick, Cale and Bashar as they chat about the spectrum of plasma cell dyscrasias, and cover the precursor conditions MGUS and Smouldering Myeloma. Timestamps 2:53 - What is a paraprotein? 5:56 - The heavy chain component 9:40 - The spectrum of plasma cell disorders 10:12 - MGUS 11:33 - How common is MGUS? 15:24 - You've found a paraprotein - what next? 17:38 - IMWG MGUS Criteria 19:47 - Mayo Score for Risk Stratification 22:25 - Serum free light chain ratio 24:25 - Bence Jones proteins 26:21 - Smouldering myeloma 27:30 - IMWG Smouldering myeloma criteria 29:16 - Risk of progression to MM Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
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Bloody Minded
A is for Antibody. B is for B-cell. C is for Cryoglobul… wait no we’ve covered that already. If you struggle to tell your thymus from an isthmus, can’t see the humour in humoural immunity and think a bursa is just some fancy elbow cushion then THIS is the episode for you. Join the Bloody Minded Crew as they dust off their undergraduate immunology degrees, get back to the classroom and cover the foundations of the immune system in preparation for tackling our upcoming malignant diseases. Timestamps 3:43 - The Immune System 4:50 - The Spleen 5:36 - The Thymus 6:19 - The Lymph Nodes 8:19 - The Innate Immune System 13:16 - The Adaptive Immune System 16:56 - VDJ recombination 21:21 - MHC/HLA 24:54 - Antibodies! 27:42 - Class switching 28:58 - The purpose of Plasma Cells 30:33 - An immune response - start to finish Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
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Bloody Minded
1 Episode 21 - On the Wards: Welcome to the Jungle | Your First Haem Ward Round 44:54
44:54 나중에 재생 나중에 재생 리스트 좋아요 좋아요44:54
나중에 재생 나중에 재생 리스트 좋아요 좋아요Help! After a disastrous 3 way ward swap you now have to cover the haem ward as an intern in... 45 minutes time. If only there were some way you could get a crash course on everything you might need to know. Well are you in luck today! Join our new guest host Dr Alison Chandler for a whole new subtype of episodes, our new "On the Wards" series. “ These are for those new interns and residents who have been drafted to cover the dreaded haem wards and need to prepare all the practical day to day things. On this inaugural On The Wards episode we'll cover the haematology ward round, how to read a haematology note and plan for some planned admissions. Keep an eye out for these every so often in between our conventional topics. Timestamps 1:09 - Who is Dr Alison Chandler? 3:43 - What makes haem scary? 8:20 - Three top tips for haem JMOs 14:34 - The haem ward round - letters and numbers! 27:50 - Always look at the blood count 34:08 - Planned admissions 38:02 - Extra things to do on haem Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
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Bloody Minded
1 Episode 20 - TMI about TLAs | TTP & PNH with Dr Danny Hsu 43:24
43:24 나중에 재생 나중에 재생 리스트 좋아요 좋아요43:24
나중에 재생 나중에 재생 리스트 좋아요 좋아요Tired of listening to the three of us? Why not listen to an actual expert!? Today we're joined by Dr Danny Hsu , consultant haematologist, clinical lead of Immune Haematology & Therapeutic Apheresis at Liverpool Hospital, THANZ council member and all around top bloke to dig down into the nitty gritty of TTP and PNH. Any question you might have about these conditions Dr Hsu is your go to. Sadly we didn't ask him every question you might have, but he certainly came up with incredible answers to the ones we asked of him. Timestamps 1:15 - Intro to Dr Danny Hsu! 7:19 - Getting into nonmalignant haem 9:55 - TTP in practice 14:03 - Intricacies of TTP diagnosis 25:15 - Managing TTP in the the longer term 28:55 - PNH chat! 38:57 - Final words and outro Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
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Bloody Minded
Have you been spending too much time outside of the lab lately? So have we! Come with us on a whirlwind tour through the high altitudes of thermal amplitudes, the chilly depths of cold agg titres, the bright lights of EMA testing, the flocculated wetlands of unstable haemoglobins (don’t ask) and more! All from the safety of the lab, of course. We don’t go outside. Timestamps 2:14 - Cold agglutinin testing 8:05 - PCH (Pretty Cool Haem)/Donath-Landsteiner testing 14:52 - G6PD testing 23:25 - Unstable Haemoglobin testing 28:55 - Take homes Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
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Bloody Minded
1 Episode 18 - Pretty Not Happy (with blood) | Paroxysmal Nocturnal Haemoglobinuria 21:22
21:22 나중에 재생 나중에 재생 리스트 좋아요 좋아요21:22
나중에 재생 나중에 재생 리스트 좋아요 좋아요Do you have a FLAER for the exotic? All at sea without your GPI-anchor? Come on a deep dive into the world of paroxysmal nocturnal haemoglobinuria - which isn’t really a disease of haemolysis at all but hey we're putting it here anyway and you can't stop us Timestamps 1:46 - What is PNH? Baby don't hurt me... 4:48 - Signs and Symptoms 7:27 - Pathophysiology 11:27 - Diagnosis 17:04 - Managing Pretty Not Happy Blood Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…
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