EP 116: Genetics and Medicine: Clonal hematopoiesis, genomics in healthcare, and a new discovery in APOL1 kidney disease with Dr. Alex Bick

The Genetics Podcast

Sano Genetics에서 제공하는 콘텐츠입니다. 에피소드, 그래픽, 팟캐스트 설명을 포함한 모든 팟캐스트 콘텐츠는 Sano Genetics 또는 해당 팟캐스트 플랫폼 파트너가 직접 업로드하고 제공합니다. 누군가가 귀하의 허락 없이 귀하의 저작물을 사용하고 있다고 생각되는 경우 여기에 설명된 절차를 따르실 수 있습니다 https://ko.player.fm/legal.

6M ago 52:34

MP3•에피소드 홈

0:00 Introduction

4:23 Insights into clonal hematopoiesis from the pioneering Framingham Heart Study

8:30 Linking clonal hematopoiesis to cancer and cardiovascular health

11:22 Interplay of germline and somatic variants in clonal expansion

17:20 How the rate of clonal expansion can provide insights into cancer and cardiovascular risk

19:00 How clonal hematopoiesis interplays with other orthogonal risk factors, including polygenic risk scores, and more established conventional heart health measures

21:00 Integration of genomic data in medical care, leading to the rise of preventative medicine

25:50 Insights into the Vanderbilt Genomics and Therapeutics Clinic

30:00 A dive into the Million Veterans Program, including the discovery of a modifier variant in the APOL1 gene related to kidney disease

44:05 How to differentiate the effects of modifier variants from risk variants in genetic studies

51:00 Individuals with APOL1 loss of function and its implications in kidney health

55:45 Closing remarks

169 에피소드

#Science #Natural Sciences #Sano Genetics #Genetics #Precision Medicine #Personalised Medicine #Personalized Medicine #Biology #DNA #Gene

EP 116: Genetics and Medicine: Clonal hematopoiesis, genomics in healthcare, and a new discovery in APOL1 kidney disease with Dr. Alex Bick

The Genetics Podcast

30 subscribers

published 6M ago