When Genes Collide: A Rare Diagnosis Reveals Complex Health Interactions with Dr. Philip Bretsky

Precision Medicine Made Simple

When Genes Collide: A Rare Diagnosis Reveals Complex Health Interactions with Dr. Philip Bretsky

For this episode, Dr. Bretsky shares a remarkable case study that unravels the complex relationship between genes and inflammation. When a patient's mysterious symptoms led to the rare diagnosis of VEXAS syndrome, it revealed an unexpected connection with cardiovascular health, demonstrating how different genetic factors can interact to amplify health risks.

Timestamps:

• 3:50 - Introduction to Lp(a) and its role in cardiovascular health
• 10:09 - Patient's initial presentation with testicular swelling
• 17:55 - Discussion of environmental factors and genetic mutations
• 23:28 - Understanding inflammation's role in cardiovascular risk
• 35:32 - Treatment decisions and stent placement
• 41:51 - Prevention strategies for inflammatory conditions
• 1:24:19 - Episode wrap-up and closing

Dr. Philip Bretsky's Contact Information:

Philip M. Bretsky MD PhD MPH FACP

1301 20th Street, Suite 230

Santa Monica, CA 90404

TEL: [phone]

FAX: [phone]

Facebook:@santamonicaprimarycare

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Web: www.drbretsky.com & www.santamonicaprimarycare.com

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Dr. William Stanford MD PHD FACP

Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.

A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine, enhancing his role as a leading expert in the field.

Sponsored by: Biography Health

Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.

Other Resources Mentioned:

https://www.cnn.com/2023/01/24/health/vexas-syndrome-prevalence-study-wellness/index.html

https://www.amazon.com/Implementation-Personalized-Precision-Medicine-Prevention/dp/0323988083