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Accelerating Antibiotic Discovery Using AI - On Tech Ethics
Manage episode 410254926 series 3440731
CITI Program에서 제공하는 콘텐츠입니다. 에피소드, 그래픽, 팟캐스트 설명을 포함한 모든 팟캐스트 콘텐츠는 CITI Program 또는 해당 팟캐스트 플랫폼 파트너가 직접 업로드하고 제공합니다. 누군가가 귀하의 허락 없이 귀하의 저작물을 사용하고 있다고 생각되는 경우 여기에 설명된 절차를 따르실 수 있습니다 https://ko.player.fm/legal.
Discusses the use of artificial intelligence (AI) to accelerate antibiotic discovery.
Our guest today is César de la Fuente who is a Presidential Assistant Professor at the University of Pennsylvania. César’s research focuses on using computational approaches to accelerate discoveries in biology and medicine. Specifically, he pioneered the development of the first computer-designed antibiotic with efficacy in animal models, demonstrating the application of AI for antibiotic discovery and helping launch this emerging field.
Related publications:
- Pioneering study describing an antibiotic designed by AI with efficacy in preclinical mouse models: https://www.nature.com/articles/s41467-018-03746-3
- First exploration of the human proteome as a source of antibiotics, yielding numerous preclinical candidates: https://www.nature.com/articles/s41551-021-00801-1
- First therapeutic molecules (i.e., antibiotics) identified in extinct organisms, launching the field of molecular de-extinction: https://www.cell.com/cell-host-microbe/pdfExtended/S1931-3128(23)00296-2
- Relevant review in Science with the Collins Lab covering this emerging field: https://www.science.org/doi/10.1126/science.adh1114
Related media coverage:
- STAT - “Giant sloths and woolly mammoths: Mining past creatures’ DNA for future antibiotics:” https://www.statnews.com/2023/10/25/antibiotics-resistance-ancient-dna-cesar-de-la-fuente/
- Vox - “Using AI, scientists bring Neanderthal antibiotics back from extinction:” https://www.vox.com/future-perfect/23811682/ai-neanderthal-antibiotics-extinction
- CNN - “Why ‘resurrection biology’ is gaining traction around the world:” https://www.cnn.com/2023/12/26/world/resurrection-biology-extinct-species-virus-scn/index.html
Additional resources:
- De La Fuente Lab: http://delafuentelab.seas.upenn.edu/
- LinkedIn: https://www.linkedin.com/in/cesardelafuentenunez/
- X: https://twitter.com/delafuenteupenn
- CITI Program’s Bioethics course: https://about.citiprogram.org/course/bioethics/
- CITI Program’s Technology, Ethics, and Regulations course: https://about.citiprogram.org/course/technology-ethics-and-regulations/
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