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LessWrong에서 제공하는 콘텐츠입니다. 에피소드, 그래픽, 팟캐스트 설명을 포함한 모든 팟캐스트 콘텐츠는 LessWrong 또는 해당 팟캐스트 플랫폼 파트너가 직접 업로드하고 제공합니다. 누군가가 귀하의 허락 없이 귀하의 저작물을 사용하고 있다고 생각되는 경우 여기에 설명된 절차를 따르실 수 있습니다 https://ko.player.fm/legal.
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[Linkpost] “introduction to cancer vaccines” by bhauth
Manage episode 426773007 series 3364760
LessWrong에서 제공하는 콘텐츠입니다. 에피소드, 그래픽, 팟캐스트 설명을 포함한 모든 팟캐스트 콘텐츠는 LessWrong 또는 해당 팟캐스트 플랫폼 파트너가 직접 업로드하고 제공합니다. 누군가가 귀하의 허락 없이 귀하의 저작물을 사용하고 있다고 생각되는 경우 여기에 설명된 절차를 따르실 수 있습니다 https://ko.player.fm/legal.
This is a linkpost for https://www.bhauth.com/blog/biology/cancer%20vaccines.html cancer neoantigens
For cells to become cancerous, they must have mutations that cause uncontrolled replication and mutations that prevent that uncontrolled replication from causing apoptosis. Because cancer requires several mutations, it often begins with damage to mutation-preventing mechanisms. As such, cancers often have many mutations not required for their growth, which often cause changes to structure of some surface proteins.
The modified surface proteins of cancer cells are called "neoantigens". An approach to cancer treatment that's currently being researched is to identify some specific neoantigens of a patient's cancer, and create a personalized vaccine to cause their immune system to recognize them. Such vaccines would use either mRNA or synthetic long peptides. The steps required are as follows:
First published:
May 5th, 2024
Source:
https://www.lesswrong.com/posts/xgrvmaLFvkFr4hKjz/introduction-to-cancer-vaccines
Linkpost URL:
https://www.bhauth.com/blog/biology/cancer vaccines.html
---
Narrated by TYPE III AUDIO.
…
continue reading
For cells to become cancerous, they must have mutations that cause uncontrolled replication and mutations that prevent that uncontrolled replication from causing apoptosis. Because cancer requires several mutations, it often begins with damage to mutation-preventing mechanisms. As such, cancers often have many mutations not required for their growth, which often cause changes to structure of some surface proteins.
The modified surface proteins of cancer cells are called "neoantigens". An approach to cancer treatment that's currently being researched is to identify some specific neoantigens of a patient's cancer, and create a personalized vaccine to cause their immune system to recognize them. Such vaccines would use either mRNA or synthetic long peptides. The steps required are as follows:
- The cancer must develop neoantigens that are sufficiently distinct from human surface proteins and consistent across the cancer.
- Cancer cells must [...]
First published:
May 5th, 2024
Source:
https://www.lesswrong.com/posts/xgrvmaLFvkFr4hKjz/introduction-to-cancer-vaccines
Linkpost URL:
https://www.bhauth.com/blog/biology/cancer vaccines.html
---
Narrated by TYPE III AUDIO.
332 에피소드
Manage episode 426773007 series 3364760
LessWrong에서 제공하는 콘텐츠입니다. 에피소드, 그래픽, 팟캐스트 설명을 포함한 모든 팟캐스트 콘텐츠는 LessWrong 또는 해당 팟캐스트 플랫폼 파트너가 직접 업로드하고 제공합니다. 누군가가 귀하의 허락 없이 귀하의 저작물을 사용하고 있다고 생각되는 경우 여기에 설명된 절차를 따르실 수 있습니다 https://ko.player.fm/legal.
This is a linkpost for https://www.bhauth.com/blog/biology/cancer%20vaccines.html cancer neoantigens
For cells to become cancerous, they must have mutations that cause uncontrolled replication and mutations that prevent that uncontrolled replication from causing apoptosis. Because cancer requires several mutations, it often begins with damage to mutation-preventing mechanisms. As such, cancers often have many mutations not required for their growth, which often cause changes to structure of some surface proteins.
The modified surface proteins of cancer cells are called "neoantigens". An approach to cancer treatment that's currently being researched is to identify some specific neoantigens of a patient's cancer, and create a personalized vaccine to cause their immune system to recognize them. Such vaccines would use either mRNA or synthetic long peptides. The steps required are as follows:
First published:
May 5th, 2024
Source:
https://www.lesswrong.com/posts/xgrvmaLFvkFr4hKjz/introduction-to-cancer-vaccines
Linkpost URL:
https://www.bhauth.com/blog/biology/cancer vaccines.html
---
Narrated by TYPE III AUDIO.
…
continue reading
For cells to become cancerous, they must have mutations that cause uncontrolled replication and mutations that prevent that uncontrolled replication from causing apoptosis. Because cancer requires several mutations, it often begins with damage to mutation-preventing mechanisms. As such, cancers often have many mutations not required for their growth, which often cause changes to structure of some surface proteins.
The modified surface proteins of cancer cells are called "neoantigens". An approach to cancer treatment that's currently being researched is to identify some specific neoantigens of a patient's cancer, and create a personalized vaccine to cause their immune system to recognize them. Such vaccines would use either mRNA or synthetic long peptides. The steps required are as follows:
- The cancer must develop neoantigens that are sufficiently distinct from human surface proteins and consistent across the cancer.
- Cancer cells must [...]
First published:
May 5th, 2024
Source:
https://www.lesswrong.com/posts/xgrvmaLFvkFr4hKjz/introduction-to-cancer-vaccines
Linkpost URL:
https://www.bhauth.com/blog/biology/cancer vaccines.html
---
Narrated by TYPE III AUDIO.
332 에피소드
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