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Behind the Scenes: Manufacturing Viruses for Hemophilia Gene Therapy
Manage episode 339547152 series 3389660
csd5r에서 제공하는 콘텐츠입니다. 에피소드, 그래픽, 팟캐스트 설명을 포함한 모든 팟캐스트 콘텐츠는 csd5r 또는 해당 팟캐스트 플랫폼 파트너가 직접 업로드하고 제공합니다. 누군가가 귀하의 허락 없이 귀하의 저작물을 사용하고 있다고 생각되는 경우 여기에 설명된 절차를 따르실 수 있습니다 https://ko.player.fm/legal.
Gene therapy promises the possibility of replacing damaged and faulty disease-causing genes with functional copies, essentially rescuing disease-causing phenotypes and restoring individuals to health. At the heart of this technology are viral vectors, little vessels that leverage the evolutionary power of viruses to penetrate and shuttle genetic information into cells.
Manipulating viruses to carry genetically-modified gene copies and then producing large quantities of these viral carriers for gene therapy is no easy task. Before any gene therapy can make it to the clinic, its feasibility and success largely hinges on critical early steps in viral vector optimization and production. In this episode, we will explore the hurdles that researchers face in viral vector development and how one team overcame these challenges to produce a groundbreaking gene therapy for hemophilia.
Drug Discovery News Talks Science is a podcast where we discuss the latest news in preclinical and translational research. Behind every medical and scientific advancement lies a harrowing story of mystery and discovery. Come with us as we share these stories and connect you to the scientific minds behind them.
This podcast episode is sponsored by Mirus Bio. Mirus Bio revolutionized transfection more than 25 years ago with the introduction of its flagship product, TransIT®-LT1. Pioneering new delivery solutions, such as TransIT-X2®, Mirus is a critical supplier of novel transfection reagents. With the introduction of TransIT-VirusGEN®, Mirus expanded expertise to virus manufacturing, supporting researchers from discovery to clinic.
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