Building Blocks of Life, AlphaFold and AI Drug Development

Agents Of Tech

In this episode of Agents of Tech, we dive into the groundbreaking advancements in AI and biotechnology with a focus on AlphaFold 3, the revolutionary AI model developed by Google DeepMind. Before AlphaFold developers Demis Hassabis and John Jumper were awarded the 2024 Nobel Prize in Chemistry for their work, this AI system had already been making waves by predicting 3D protein structures with unprecedented accuracy.
Join hosts Stephen Horn and Autria Godfrey as they explore the profound impact AlphaFold is having on science, from understanding the building blocks of life to accelerating drug discovery. We speak with Dr. Luke Yates, Assistant Professor at the University of Sussex, who explains how AlphaFold 3 is changing the landscape of biological research. We also hear from Dr. Kyle Rohde of the University of Central Florida, whose lab is using AI to speed up the development of new antibiotics, particularly for drug-resistant tuberculosis.
Recorded prior to the Nobel Prize announcement, this episode offers an insightful look into the future of AI-driven discoveries in biology, medicine, and beyond. Don’t miss out on this fascinating discussion!
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00:00 - Welcome to Agents of Tech
00:13 - Hosts Introduction
00:19 - Exploring Life's Building Blocks & Antibiotic Development
00:54 - Upcoming Guests & Topics
01:00 - Interview with Dr. Luke Yates on AlphaFold 3
03:20 - The Significance of Protein Folding
06:12 - Impact of AlphaFold on Disease Research
10:30 - Challenges in Drug Discovery
13:05 - Open-Source Debate on AlphaFold
16:10 - Ethical Concerns of AI in Biology
18:00 - Interview with Dr. Kyle Rohde on TB Drug Discovery
20:30 - How Multidrug-Resistant TB Complicates Treatment
23:40 - AI and Target-Based Screening for New Antibiotics
27:40 - The Future of AI-Driven Drug Discovery
31:00 - Closing Remarks & Next Episode Preview
32:00 - Subscribe to Agents of Tech