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Featuring articles on omecamtiv mecarbil in systolic heart failure, sotagliflozin in diabetes with heart failure, sotagliflozin for heart failure in diabetes and kidney disease, bupropion and naltrexone for methamphetamine use, and procuring oligodendrocytes after spinal cord injury; a review article on Ewing’s sarcoma; a case report of a woman wit…
 
Featuring articles on sitagliptin for prevention of acute GVHD, tocilizumab in Covid-19 pneumonia, rilonacept in recurrent pericarditis, vaginal mother-to-child transmission of cancer, and on whether the melanoma epidemic is real; a review article on osteoarthritis of the knee; a Clinical Problem-Solving on breathing for two; and Perspective articl…
 
Featuring articles on the safety and efficacy of an RNA-based SARS-CoV-2 vaccine, dexamethasone in chronic subdural hematoma, sleuthing out a severe adult inflammatory disorder, hemoglobin transfusion thresholds in infants, and vaccinating against SARS-CoV-2; a review article on the pathophysiology of inflammatory bowel diseases; a case report of a…
 
Featuring articles on ultrasound subthalamotomy for Parkinson’s disease, antenatal dexamethasone for early preterm birth, oral azacitidine maintenance therapy for AML, paclitaxel-coated devices in peripheral artery disease, and seizure frequency during pregnancy; a review article on estrogen receptor–positive breast cancer; a case report of a man w…
 
Featuring articles on SARS-CoV-2 transmission among Marine recruits, SARS-CoV-2 transmission on an aircraft carrier, an mRNA vaccine against Covid-19 in older adults, a phase 1 trial of an RNA-based Covid-19 vaccine, and the cardiomyocyte and the mighty mitochondrion; a review article on severe Covid-19; a case report of a boy with seizure and hypo…
 
The COVID-19 pandemic has exposed the magnitude of health inequities that exist today. In this Curbside Consults as part of our “Inclusivity in Medicine” series, Dr. Jim O’Connell, President of the Boston Healthcare for the Homeless Program joins us to discuss how the...저자 NEJM Group
 
Featuring articles on lipid lowering through activation of lipoprotein lipase, on a SARS-CoV-2 recombinant nanoparticle vaccine, on tocilizumab in Covid-19, and on survival with olaparib in prostate cancer; a review article on spontaneous coronary-artery dissection; a case report of a man with cancer and acute hypoxemia; and Perspective articles on…
 
Patients who clinically deteriorate on medical and surgical wards suffer substantial morbidity and mortality. Identifying patients who are at risk for clinical deterioration provides an opportunity for early intervention. Complex automated models that use the vast data...저자 NEJM Group
 
Obesity is a major cause of morbidity in the United States and many other high-income countries. Its association with diabetes, hypertension, cardiovascular disease, and ultimately reduced life expectancy is well known. A healthy diet and regular exercise can prevent...저자 NEJM Group
 
In this special episode of Curbside Consults, we interview Dr. Elissa Falconer, the team leader of the NEJM Resident 360 QI Challenge winning submission. Dr. Falconer is a general surgery resident at Atlanta VA Healthcare System. The title of their quality improvement...저자 NEJM Group
 
Eric Rubin is editor-in-chief of the New England Journal of Medicine. I asked him how Covid-19 has affected that journal, which has been around since the War of 1812 and seen its share of pandemics. Listen in — it’s the first in a planned series of interviews with the editors of the principal clinical journals. Running time: 19 minutes NEJM’s Covid…
 
The coronavirus pandemic has meant that for one of the first times ever, the entire world is experiencing the same thing at the same time. It has given me pause to think though, isn’t this exactly what climate change has been trying to highlight all along- that climate...저자 NEJM Group
 
Dr. Paul Sax writes the closest thing that the NEJM Group has to humor. He’s serious, of course, since his blog “HIV and ID Observations” concerns all things infectious . But he sprinkles in the odd cartoon or links to … dog videos, fer cryin’ out loud. He scours the ID literature (and we must include the social-media literature in that category) f…
 
Back in late March (people often tell me that, these days, 4 months ago might as well be 4 years ago) we talked with emergency physician Julian Flores, who was working out of Broward County. Covid-19 cases were modest in number but threatening to get worse, and indeed they did. The county’s cases jumped 100-fold, from about 600 to over 50,000. Just…
 
Don’t expect HIPAA regulations to protect your “digital health footprint” from prying eyes. Every time you swipe your card to buy goodies at the supermarket (are you risking diabetes with all that ice cream?), or binge-watch that kinky series (how’s your mental health these days, really?), or let your step-tracker show you’ve fallen off the pace (c…
 
The COVID-19 pandemic has forced innovation in health care in many ways, one of which is putting to test advances in digital health. There has been no better time to test its value than in this environment of social distancing, reduced contact, and heightened health...저자 NEJM Group
 
We interview Dr. Michael Gonzalez, a Houston-based emergency physician, who describes the situation there as “an ongoing, slow-rolling, level 6 hurricane that just isn’t gonna go away and, more importantly, isn’t gonna tell us when landfall is coming and when it’s gonna be over.” How are his patients reacting to this surge? What does he do to prepa…
 
This time Dr. Ali Raja and Joe Elia talk with two authors of a study that found disparate effects on traffic deaths from the legalization of recreational cannabis. The two states under study, Colorado and Washington, were compared, not with each other, but with a composite of states that most closely resembled what Colorado and Washington would be …
 
In this episode of Curbside Consults: Statistical Review, we explore the interpretation of secondary outcomes in clinical trials using the following two articles recently published in NEJM: Bonaca MP et al. Rivaroxaban in Peripheral Artery Disease after Revascularization...저자 NEJM Group
 
In today’s podcast we are joined by Dr. Marc Bonaca to discuss the findings of the recent VOYAGER PAD trial and the use of low-dose rivaroxaban in peripheral artery disease after revascularization.저자 NEJM Group
 
The novel coronavirus obviously has devastating effects on the lungs, but other, less immediately visible attacks occur — notably to the kidneys. Dr. Steven Fishbane (a nephrologist) and his colleagues have just published their findings based on a survey of some 5500 patients with COVID-19 admitted to a metropolitan New York health system. Acute ki…
 
A combination of three antivirals — Kaletra (which is lopinavir plus ritonavir) and ribavirin — when given early and with interferon significantly reduces viral shedding, disease symptoms, and hospital stay in patients with COVID-19 when compared with a control regimen of Kaletra alone. The drugs are active against other coronaviruses, but the key …
 
We (Dr. Danielle Bowen Scheurer and Joe Elia) talk with Dr. John Jernigan of the CDC COVID-19 Investigation Team, which recently published its findings on the spread of COVID-19 in a Seattle-area skilled nursing facility. Most intriguingly, over half the patients who tested positive were asymptomatic at the time of their first testing, and a few ha…
 
Cardiovascular consults are way down. Is the threat of COVID-19 infection scaring people away from EDs? We caught up with Dr. Comilla Sasson, the American Heart Association’s VP for science and innovation. She’s an emergency physician who teaches at the University of Colorado. She’d traveled to New York City to “help with the response,” and she tal…
 
In this episode of Curbside Consults, we continue our exploration of the prescription and use of opioids in the treatment of chronic pain. We hear a patient’s point of view, exploring how a patient with chronic pain manages his relationship with his provider, pharmacy, and...저자 NEJM Group
 
This week’s guests, Dr. Andre Sofair and Dr. William (“Rusty”) Chavey are physician-editors on the daily clinical news alert called Physician’s First Watch. I went back through the recent issues and found this January 10 entry, which began “The CDC is requesting that clinicians ask their patients with severe respiratory disease about any travel to …
 
Four weeks ago — in early March — I interviewed Dr. Renee Salas about climate change and clinical medicine. Back in those halcyon days, COVID-19 was very much a gathering storm, but it had not yet slammed into the United States. Here we are, over 10,000 U.S. deaths later in early April, not having heard of much […]…
 
In this statistical review episode of Curbside Consults, we explore descriptive epidemiology studies of the COVID-19 outbreak using an article by Guan and colleagues published online in NEJM on February 28, 2020. To help explain the approach to outbreak study analysis...저자 NEJM Group
 
We talk with Colleen Farrell who’s doing her third year of an internal medicine residency in New York City. Fortunately, we caught her during a one-week vacation (she was supposed to be taking two), and she chatted with us about how she and her colleagues are coping. We asked her what she thought COVID-19’s larger lessons would […] The post Podcast…
 
San Diego County has Dr. Kristi Koenig as medical director of its emergency medical services. That’s fortunate for the county, because she’s co-edited a definitive textbook, “Koenig and Schultz’s Disaster Medicine: Comprehensive principles and practices.” We’re fortunate to have her as our guest. She’s full of sound advice on organizing a community…
 
This time we talk with Dr. Julian Flores, who works in a Broward County, Florida, emergency room. When he was interviewed, the count of Covid-19 cases stood at 412, less than 12 hours later, the new number was 505, as of this posting — on Friday near noon Eastern — it’s at 614. Flores is expecting […]…
 
Dr. Matt Young is a first-year resident in obstetrics and gynecology in suburban Delaware. Between the day I invited him to be interviewed and the interview itself (a 36-hour span) things had changed a lot for him. Anxiety levels are up among his colleagues, and everyone in his hospital must wear a mask all the time. […]…
 
Managing patients with chronic pain is a constant challenge for physicians. We frequently receive questions from clinicians about handling these complex situations. Questions about prescribing opioids include when to use opioids and how to monitor their use. In this...저자 NEJM Group
 
We talk with Susan Sadoughi, an internist at Brigham & Women’s Hospital in Boston, about how quickly things have changed over the past week. Last week, I introduced the Fauci interview by saying that I’d heard a clinician complain that she’d spent half her time answering questions about COVID-19. This week, she’s our guest, and she’s […]…
 
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