Malaria 공개
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In this podcast, Silas Majambere discusses with various experts the issues of inequity in global health and in particular the inadequacy of malaria control strategies in Africa. Silas Majambere is a Public Health Entomologist who has spent 20 years of his career studying and fighting mosquitoes that transmit malaria. If you are interested in global health equity, and the intricacies of poverty and international aid, this podcast is for you.
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An innovative, non-invasive diagnostic tool that could revolutionize malaria testing, with the potential to be built into wearable devices. In this extended episode of the Johns Hopkins Malaria Minute, we ask: What are the limitations of current malaria diagnostic methods? How is a 'cytophone' - and what makes it innovative? Why is the detection of…
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Using lasers and ultrasound, the ‘cytophone’ detects a key byproduct of all malaria parasites. Transcript Among the most commonly used malaria diagnostic tests is the rapid diagnostic test (RDT), which detects malaria antigens from a drop of blood. Whilst RDTs are small and cheap, they're invasive and new strains of the parasite have evolved that c…
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Today, how DNA from a single patient in Ethiopia can shed light on the big picture of malaria. Why is Plasmodium vivax significant in malaria research, especially in Ethiopia? How does genomic sequencing contribute to understanding and controlling malaria? How are advances in sequencing technology influencing malaria research? With Jane Carlton, De…
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'Comparative genomics' helps identify genes that can serve as targets for future drugs and vaccines. Transcript Not all parasites are alike. Genetic mutations mean that malaria parasites evolve differently in different regions – and even within the same region. One species thought to be particularly genetically diverse is Plasmodium vivax. It’s the…
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The World Health Organisation has recommended two licenced malaria vaccines. Those vaccines have been a long time coming - but are they the best? In this extended episode of the Johns Hopkins Malaria Minute, we ask: Why is developing a malaria vaccine so challenging? How does antigen variation play affect the effectiveness of malaria vaccines? What…
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A key challenge in developing a malaria vaccine is choosing which stage to target. Transcript A key challenge in developing a malaria vaccine is choosing which stage of the infection to target. You can target the parasite when it enters the body, multiplies in the liver and the blood, or is in the sexual stage, preparing to be picked up by a mosqui…
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We share a special episode of our podcast to mark World Mosqutio Day. World Mosquito Day, observed annually on August 20th, commemorates British doctor Sir Ronald Ross's discovery in 1897 that female Anopheles mosquitoes transmit malaria to humans. More than a century later, major advancements like genetically modifying mosquitoes—AKA gene drives—h…
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People often talk about the 'malaria toolkit' - how might gene drives fit? Transcript When people talk about malaria, they often mention the 'malaria toolkit' – a set of tools, like bed nets and indoor residual spraying, that are available to help curb the spread of disease. In the past, these tools were trusty go-to's – thanks to their efficacy, s…
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Gene drives are a novel way of genetically editing the mosquitoes that transmit malaria. They have the potential to dramatically reduce cases and deaths. But the technology they’re based on is new and requires new thinking on regulation. In this first episode of our two-part focus on gene drives, we ask how drives work – examining the CRISPR techno…
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Gene drives are a promising tool for malaria control - how can we tell they actually work? Transcript Gene drives are a promising new tool for malaria control. They involve releasing genetically modified mosquitoes into the wild – mosquitoes engineered to halt the parasites from developing inside the insects, or that cause the mosquitoes to die. Th…
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Temperature, rainfall, and humidity determine malaria transmission - but climate change is altering each one of those variables. What might this mean for cases of the disease? With Alex Eapen, from the ICMR (Indian Council of Medical Research) in Chennai, India. About The Podcast The Johns Hopkins Malaria Minute is produced by the Johns Hopkins Mal…
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Researchers compare the temperature of mosquito breeding spots with a decade early to examine its impact on malaria transmission. Transcript The effects of climate change on malaria are becoming clearer. Anopheles stephensi – an urban form of the malaria mosquito – is changing its geography, moving from Southeast Asia to parts of Africa and India. …
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A single protein helps malaria parasites develop in the blood and cause disease symptoms. Could inhibiting this essential protein help curb the spread of disease? With Abhishek Kanyal and Krishanpal Karmodiya. About The Podcast The Johns Hopkins Malaria Minute is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malari…
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A poorly studied malaria protein could serve as a key drug target to help combat the growing problem of resistance. Transcript A poorly studied malaria protein – Plasmodium falciparum histone deacetylase 1 – could serve as a key drug target to help combat the growing problem of resistance. The protein helps regulate the ‘intraerythrocytic’ stage of…
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Dr Fitsum Tadesse is a Lead Scientist at the Armauer Hansen Research Institute (AHRI) in Ethiopia, a Wellcome Trust Fellow at LSHTM and an Alan J. Magill Fellow at ASTMH His work mainly focuses on the transmission of malaria parasites from humans to mosquitoes. His group recently demonstrated the contribution of the invasive mosquito, Anopheles ste…
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How sickle cell disease can be a blessing and a curse. And why we need equity in genomic research and to diversify the genomes we sequence. With Ambroise Wonkam (Johns Hopkins University). About The Podcast The Johns Hopkins Malaria Minute is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malaria research and to sha…
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Malaria is one of humanity’s oldest diseases – and one with which we have evolved. Transcript Malaria is one of humanity’s oldest diseases – and one with which we have evolved. Over time, it’s put selective pressure on our genome to respond better to its infection. Sickle cell disease is one example. It causes a defect in hemoglobin – transforming …
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Dr Anne Gasasira is a Ugandan trained medical doctor and epidemiologist. She started her career in malaria and HIV research in the early 2000s. She worked on a research collaboration between Makerere University- University of California San Francisco on antimalarial drug efficacy and HIV–Malaria interaction studies. Since 2015, has been working wit…
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On the steps of Capitol Hill, we meet the scientists bringing their scientific battle against malaria into the world of political advocacy. They join a 100+ group of advocates lobbying their members of Congress to fund critical interventions against malaria – becoming ‘malaria champions’ as well. We ask: Why have they decided to join the world of p…
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Malaria champions from 43 states gather in Washington D.C. to lobby their members of Congress about malaria. Transcript The malaria community is diverse. Some work on the parasites, others the mosquito. Others still focus on public health. The battle is being waged on the bench and the field. But there's another community fighting the disease on a …
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Until recently, health workers were the only means to prevent and treat malaria in Odisha, India. In 2017, the state government tried a new strategy: pooling health resources into regional ‘malaria camps’. In this podcast, we ask: What is the current state of malaria in Odisha, India? What challenges does Odisha face in malaria control, especially …
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Malaria in India has fallen in recent decades — but the risk is still high among hard-to-reach communities. A new study has evaluated the system of ‘malaria camps’ — in which health workers provide targeted interventions before the monsoon. Transcript Malaria in India has diminished in past decades — yet the risk is still high among hard-to-reach c…
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A new documentary tells a story of global scientific collaboration in the development of a new malaria vaccine, R21. Today, we take you behind the scenes with director and producer, Catherine Gale. In this podcast, we ask: Why are malaria vaccines gaining so much attention now? What was the serendipidous origin of the documentary? What are the key …
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Carl Manlan is an Economist working at the intersection of public, private and civil society sectors. He is a development practitioner with experience in health financing, private foundations, inclusive impact and sustainability.저자 Silas Majambere
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A new documentary from NOVA shines a light on the creation of R21, a new malaria vaccine. Transcript This month, a new documentary from NOVA shines a light on the creation of a new malaria vaccine. ‘The Battle to Beat Malaria’ tells the story of the development of R21 – from creation to WHO approval. Taking you behind the scenes in Oxford, UK, wher…
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Sherwin Charles is a co-founder and the Chief Executive Officer of Goodbye Malaria, an African initiative to eliminate malaria in Southern Africa. In this episode we discuss his journey into the fight against malaria, the role of the private sector and the financing of malaria elimination; the current reliance on commodities and the role of communi…
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As COP28 emphasises the human cost of climate change, what will be the impact of rising temperatures and extreme weather events on malaria transmission? In this podcast, we ask: How was health represented this year at COP? What is the impact of rising temperatures on malaria? How will extreme weather events, like flooding, affect malaria prevalence…
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The WHO launches its annual World Malaria Report at COP28, the UN's Climate Change Conference. Transcript The World Health Organization (WHO) has released its World Malaria Report for 2023 at the start of COP28, the UN’s Climate Change Conference. The headline figures are concerning. The WHO estimates that there were 249 million cases of malaria la…
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Dr Michael Adenkule Charles is the CEO of the RBM Partnership to End Malaria. He is at the forefront of convening and collaborating with over 500 partners, in the combined mission towards the elimination of malaria. In this episode, I chat with Dr Charles about the issues of localization and agenda setting for malaria elimination in Africa; the ove…
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An old malaria drug gets a new formulation. But how good is it – and will it drive resistance? In this podcast, we ask: What are the limitations of current malaria vaccines? What is the concept of long-acting injectable (LAI) drugs? What are the clinical and chemical properties of atovaquone that make it suitable for this purpose? With Theresa Shap…
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How ‘chemical vaccines’ could offer long-term protection against malaria in endemic areas, and combat the problems of dosing and drug resistance. Transcript Drugs used to prevent and treat malaria are vital tools in the malaria toolkit – but they aren’t perfect. When used to prevent malaria, people must remember to take them regularly, or they won’…
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Drug efficacy studies are revealing the spatial distribution of mutations causing artemisinin resistance - and it all starts with a drop of blood. In this podcast, we ask: What is artemisinin resistance? What are some of the key molecular markers underpinning it? How can we overcome it? With Didier Ménard, Director of the Institute of Parasitology …
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Researchers examine the rise of artemisinin drug resistance in Eritrea - and search for its genetic basis. Transcript Artemisinin – a key antimalarial drug – and other drugs derived from it, are fast losing their effectiveness across South East Asia and increasingly in Africa, too. To investigate this, researchers conducted a review of drug efficac…
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Mentors are instrumental in the professional and personal growth of healthcare professionals. However, mentoring relationships often fail to realize their full potential. Attendees will be encouraged and equipped to initiate mentoring relationships that provide both mentor and mentee with a rewarding experience.…
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In 1951, malaria was eliminated from the US. But just this past summer, the parasite that causes the disease has re-infected local mosquitoes and caused a handful of cases of malaria in three US states. In this interview podcast, we ask: What should we make of these cases? Is the public possibly at risk of this once-eliminated disease? How can geno…
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Malaria returns to the US for the first time in decades. We share what we know so far. Transcript Today, another reminder that infectious diseases respect no borders. Malaria, a disease that was once endemic globally, has returned to the US for the first time in two decades. A number of cases have been confirmed in Florida, Texas and, most recently…
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Yacine Djibo founded Speak Up Africa in 2011 to discover and implement effective, sustainable solutions to the most challenging problems facing the African people. Focusing on strategic communications, policy and advocacy, Speak Up Africa is dedicated to collaborating with African leaders and citizens to take on issues such as malaria, neglected tr…
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In this session, It will seek to help guide you on how to respond to God’s Command and Commission, The quest for discovering and following God’s will and purpose for one’s life is often an illusion to many children of the Living God, Many believers resorts to imitating others and or live a hypocritical phantom life as they are tied down to daily en…
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In 2013, on the outskirts of Madrid, GSK was gearing up to test new medicines against malaria. But they had a problem. In this month's podcast, we're joined by Janneth Rodrigues from GSK, Marcelo Jacobs-Lorena from Johns Hopkins University, and Etienne Bilgo from IRSS to share a story of collaboration that spans three continents, and which turned a…
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Are you comfortable asking people for money? Do you understand the critical areas you must address if you are going to ask people to invest in you? This session will give you an understanding of the basics in fundraising that is fundamental to anyone in ministry. You will learn 5 critical things you must do in order to raise your own support. There…
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Yacine Djibo founded Speak Up Africa in 2011 to discover and implement effective, sustainable solutions to the most challenging problems facing the African people. Focusing on strategic communications, policy and advocacy, Speak Up Africa is dedicated to collaborating with African leaders and citizens to take on issues such as malaria, neglected tr…
  continue reading
 
A naturally occurring bacterium renders the mosquito a poor transmitter of the malaria parasite. Transcript Scientists often grow mosquitos in the laboratory and infect them with malaria parasites to test new drugs and explore vector control. Unexpectedly, in a lab run by GSK in Spain, mosquitoes gradually lost the ability to sustain parasite devel…
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This session will consider case studies of biomedical research in mission contexts, derive best practices in biomedical research that enhance the work of mission institutions, and describe how to get involved in biomedical research in faith-based settings. Presentation Slides: https://bit.ly/gmhc2022_marktopazian_biomedicalresearchandfaith…
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In this episode we pick up from where we left in part 1 and discuss the issues of agenda setting, the moral imperatives around malaria control… We end this episode discussing human dignity and the reasons for remaining hopeful in this world despite all the challenges we face.저자 Silas Majambere
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After decades of research, the world’s first malaria vaccine is finally being rolled out in Africa. It’s a landmark in malaria success – but will it deliver a public health victory? In this podcast, we reveal the elusive target of the malaria vaccine and unpack the complex story of its development.
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To locate blood vessels and establish infection, malaria parasites alternate between two states of movement in the skin – fast and slow. Interestingly, this shift in state might be guided by a cell found on the walls of capillaries. Transcript Of the dozens of malaria parasites the mosquito injects, only a handful will make it. To survive, the para…
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According to the WHO, in the African Region, about 473 000 children die from pneumonia, 300 000 from diarrhea, and a further 443 000 from malaria every year. Mortality in hospitalized cases of severe pediatric malaria is 9%-10%. Many efforts to prevention infection and improve nutrition so as to modulate the impact of infection are in place but whe…
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