micheal Cover art photo provided by Vincent Burkhead on Unsplash: https://unsplash.com/@creativejunkie
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By: Becca Neil and Katie Waldvogel Cover art photo provided by Євгенія Височина on Unsplash: https://unsplash.com/@eugenivy_reserv
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Crispr and how it will benefit people with Duchennes Muscular Dystrophy. Cover art photo provided by Nahil Naseer on Unsplash: https://unsplash.com/@nahilnaseer
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Welcome to the CRISPR revolution. Take a break and join us as we guide conversations with an expert CRISPR cast about this cutting-edge science.
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CRISPR is a new technology able to edit the genes of plants to make them stronger, healthier, and more abundant. In a world facing global warming and climate change, unconventional science may be our only hope. Cover art photo provided by Johannes Plenio on Unsplash: https://unsplash.com/@jplenio
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for school :) Cover art photo provided by bharath g s on Unsplash: https://unsplash.com/@xen0m0rph
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Hosted by Dr Antony Adamson (The University of Manchester), the 'CRISPR unedited' podcast brings together researchers from around the world to share their practical knowledge on CRISPR to help you get the most out of your research. This set of engaging, fun, and energetic conversations serves to highlight the latest and upcoming CRISPR technologies, and provide helpful advice no matter where you are in your CRISPR journey.
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The effects CRISPR-cas9 has on rice and the world overall
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In this Podcast I talk about CRISPR and how it cures DMD Cover art photo provided by David Jorre on Unsplash: https://unsplash.com/@davidjorre
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Hosted by Kevin Davies, PhD, GuidePost is an exciting podcast series featuring candid conversation with the pioneers and practitioners of CRISPR and gene editing research. Guests have included luminaries Emmanuelle Charpentier, Francisco Mojica, Rodolphe Barrangou, Virginijus Siksnys, Sylvain Moineau, and Jakob Sherkow, among others. GuidePost is produced by The CRISPR Journal, the only peer-reviewed journal dedicated to the science and applications of gene editing.
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A single scientific breakthrough changed the future of humanity, setting off the third great revolution of modern times. As with any revolution, things didn’t happen neatly or quietly. One figure stood at the center of it all: Jennifer Doudna, the Nobel Prize-winning biochemist who co-created CRISPR. Her invention signified the arrival of a newfound ability to edit our genes, as simply as we edit a sentence, with a word processor. From Walter Isaacson - the bestselling biographer behind Musk ...
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In the four years since the book’s publication, CRISPR has revolutionized the world of medical treatments and possibilities. But our world has changed drastically, too. As AI’s impact grows, U.S scientists are facing funding cuts like never before. For our final episode, we bring you a live conversation between Walter Isaacson and Jennifer Doudna a…
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As the gene editing field kept growing, so did the dangers. Back in 2018, Jennifer Doudna received an email from a Chinese scientist claiming that he had genetically edited two twin babies. The news reverberated across the world and made Doudna and her colleagues urgently consider the implications of what their discovery could mean for humanity. Wa…
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Jennifer Doudna thought she had won the race. She thought she had beaten out all scientific competitors when she and her co-author had shocked the world with their groundbreaking technology for gene editing. But turned out, the race had just gotten fiercer. Walter Isaacson sits down with Evan to talk about how one of the most cutthroat scientific c…
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Back in the 1990s, a young microbiologist in Alicante, Spain became obsessed with a strange pattern he observed in the genes of tiny organisms — a series of inexplicable clusters. And he wasn’t alone. All around the world, a network of scientists were growing curious as to what these genetic knots could be and all of their potential functions. Thei…
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Earlier this year, when the world learned the news of baby KJ successfully undergoing the first personalized genetic treatment, it represented a milestone for researchers and patients. But behind this scientific feat there’s the story of the technology that made it possible, CRISPR, and one of the key pioneers behind it — Jennifer Doudna. Evan sits…
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ON CRISPR: The Story of Jennifer Doudna with Walter Isaacson
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3:27Walter Isaacson - bestselling biographer behind Musk, Einstein and Steve Jobs - in conversation with Evan Ratliff brings you behind the scenes of The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race. The story of the third great technological revolution in modern times. See omnystudio.com/listener for privacy informatio…
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In this final episode of our series, host Evan Ratliff and biographer Walter Isaacson discuss Benjamin Franklin's remarkable late-in-life achievements-- from his last anonymous essay, to the way he empowered George Washington, to his evolution on slavery, to the beautiful way Philadelphia mourned its favorite son... oh, and they discuss Ben Frankli…
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After retiring at the age of 42, Ben Franklin immersed himself in politics, taking on enormous diplomatic challenges on behalf of Pennsylvania and the colonies. In this episode, we dive into Franklin the talented statesman-- a man who emerged from his mission in England with a taste for revenge, charmed the French into supporting a burgeoning natio…
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Few people remember that Benjamin Franklin was America’s wealthiest self-made man. After being denied a formal education and then indentured to his own brother, he launched America's first media empire. But while Franklin could be a ruthless businessman, he was out for more than himself—he knew his success was predicated on a strong middle class, a…
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ON BENJAMIN FRANKLIN Episode 2: The Great American Character
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32:33From writing under pen names in the newspaper as a teenager, to the Poor Richard maxims we all know, to the autobiography he created to show the path toward American virtues, Ben Franklin literally wrote the books on what it means to be American. But how close was the real Ben Franklin to the character he created? See omnystudio.com/listener for pr…
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From Walter Isaacson– the bestselling biographer behind Musk, Einstein and Steve Jobs– and journalist Evan Ratliff (Shell Games, Longform) comes a revealing look into the life of Ben Franklin, and how his genius shaped America. In this first episode of five, we dive into the way Franklin's scientific curiosity laid the groundwork for his approach t…
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Introducing Season 2: ON Benjamin Franklin with Walter Isaacson
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2:48Introducing ON Benjamin Franklin with Walter Isaacson - an intimate behind the scenes interview to understand Benjamin Franklin’s remarkable life. See omnystudio.com/listener for privacy information.저자 iHeartPodcasts and Kaleidoscope
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Imran House and Junyun Lai Discuss CRISPR Screening in Immuno-Oncology
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26:06Imran House, Ph.D. and Junyun Lai Ph.D. are Senior Scientists at the biotech start-up, oNKo-Innate in Melbourne, Australia that focuses on developing immuno-oncology therapies. In this episode, they discussed what they do at oNKo-innate, their career transitions from leaving academics to entering the biotech industry, and how CRISPR is impacting ca…
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Which of Musk’s efforts will mark his legacy? Will it be Starship and his work bringing Americans back into orbit, or will it be X and his amplifications of the worst of humanity? Isaacson wrestles with his time in Silicon Valley, and relays a comparison of Jobs and Musk that’s sure to stay with you. See omnystudio.com/listener for privacy informat…
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Be a storyteller, not a preacher. That was novelist Walker Percy’s legendary advice to a young Walter Isaacson. One he takes to heart in his work as a journalist at Time and CNN, and as a biographer of creative genius across the centuries—and in trying to capture someone as volatile as Elon Musk. He reflects on the challenges of holding the complex…
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What kind of titan of industry has a "giddy mode"? Or a "demon mode"? The two aspects of Musk’s personality are forces that drive his choices and behavior at work—and vectors Isaacson finds critical to understanding how Musk operates. From ripping out servers on Christmas Eve on a whim to buying Twitter against better wisdom, and reaming out staff …
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Space travel, electric vehicles, future-powering batteries—the ability to push technology forward and to bring it into the world in a real way is without a doubt the best of Elon Musk. In his 600 page biography, Walter Isaacson chronicles a man with superlative engineering skills, but who “doesn’t have a fingertip feel for social emotional networks…
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See omnystudio.com/listener for privacy information.저자 iHeartPodcasts and Kaleidoscope
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Mark DeWitt and Don Kohn Discuss Their ex vivo CRISPR-based Therapy to Cure Sickle Cell Anemia
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33:24Dr. Mark DeWitt Ph.D., Associate Director at Mammoth Biosciences, and Dr. Don Kohn M.D., distinguished professor and Director of the UCLA Human Gene and Cell Therapy Program and CIRM grantee sat down with us to discuss their latest clinical trials to cure sickle cell anemia, how synthetic guides accelerated their journey from the bench to the clini…
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Dina Simkin, Professor of Neurology at Northwestern University, joins us in this episode of CRISPR Cuts. Dr. Simkin talks about her path to becoming a researcher, art, and the importance of patient and isogenic iPSC models to study genetically linked forms of epilepsies.저자 Synthego
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CRISPR Unedited featuring Bernhard Schmierer (Karolinska Institutet)
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36:05#3 — In this episode of CRISPR Unedited, Antony Adamson is joined by Bernhard Schmierer, Researcher at the Karolinska Institutet who heads the CRISPR Functional Genomics Facility at SciLifeLab. They discuss the day-to-day practicalities of performing CRISPR screens, share the vast number of cells needed for screening and highlight key literature yo…
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Sunil Sharma and Raffaella Soldi Talk CRISPR For Unbiased Drug Screening for Rare Pediatric Cancers
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24:43Dr. Sunil Sharma and Dr. Raffaella Soldi of the Translational Genomics Research Institute chat about using CRISPR arrayed screens to identify novel drug targets for Ewing's Sarcoma, outlooks for the future of cancer therapies, and the Arizona heat.저자 Synthego
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CRISPR Unedited featuring Pia Johansson (Lund University)
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48:26#2 — In this episode of CRISPR Unedited, Antony Adamson is joined by Pia Johansson, Scientific Coordinator at the Cell and Gene Therapy core at Lund University. Together they answer your practical questions about CRISPR gene editing, covering topics such as transfection, off-target effects, and the difference between CRISPRi and RNAi. The inspirati…
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Stephanie Cherqui Discusses Clinical Development of CRISPR Therapies for Rare Diseases
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20:27Professor Stephanie Cherqui, UCSD, has worked on the development of cell therapies for two rare genetic diseases, cystinosis and Friedreich’s ataxia. In this interview, Dr. Cherqui chats about her experience working on rare diseases, developing a CRISPR-edited therapy for Friedreich's ataxia, navigating regulatory challenges in cell and gene therap…
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CRISPR Unedited featuring Matthew Cobb (University of Manchester)
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51:41#1 — Matthew Cobb is Professor of Zoology at the University of Manchester. In this episode, Matthew joins our host Antony Adamson to chat about the exciting early days of genetic manipulation and some of the fears that prompted the scientists involved to build new safeguards and self-regulation. They discuss gene editing, the advent of CRISPR, and …
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Hosted by Dr Antony Adamson (The University of Manchester), the 'CRISPR Unedited' podcast brings together researchers from around the world to share their practical knowledge on CRISPR to help you get the most out of your research. This set of engaging, fun, and energetic conversations serves to highlight the latest and upcoming CRISPR technologies…
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Christian Groendahl On Pioneering a CRISPR-based Microbial Gene Therapy
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29:11Tune in to hear Christian Groendahl, CEO of SNIPR Biome, talk about CRISPR editing in prokaryotes, their novel E. coli-targeting CRISPR therapy trials, and his experiences and vision leading a start up.저자 Synthego
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Bryan Dechairo Envisions an Accessible Future for CRISPR Diagnostics
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35:29In this episode, Bryan Dechairo, CEO of Sherlock Biosciences, talks about the impact of technology advances in the field of CRISPR diagnostics, his experiences leading Sherlock Biosciences, and his team’s mission of accessibility.저자 Synthego
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Dr. Ayal Hendel, a genome-editing pioneer and group leader at Bar Ilan University in Israel, was one of the first researchers to use modified synthetic sgRNA to edit primary cells with CRISPR. In this episode, Dr. Hendel shares his perspectives on the recent CRISPR advancements and his work on the bubble boy disease.…
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Jimi Olaghere Opens up About His Sickle Cell Disease and CRISPR Trial
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39:59Jimi has dealt with sickle cell disease, a genetic disorder with serious implications, his entire life. Undergoing a CRISPR gene editing trial turned his hope for a cure into reality with promising results from the early phases. Tune in to learn about Jimi's journey in this episode.저자 Synthego
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TJ Cradick Speaks About Their HIV CRISPR Therapy in Trials
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23:40TJ Cradick, Chief Scientific Officer at Excision Bio, discusses their CRISPR HIV therapy that recently proceeded into clinical trials in this episode and their ongoing work on other viral diseases.저자 Synthego
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Bryce Olson Relays His Experience on Personalized Therapies for Cancer Patients
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42:37After being diagnosed with aggressive prostate cancer, Bryce Olson quickly learned the science behind it and has leveraged NGS to understand his tumor genomics and find opportunities in personalized therapies. Hear the patient perspective for the first time on our podcast through Bryce's narration of his experience and pursuit of next generation ce…
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Neville Sanjana Discusses Ways to Enhance CRISPR-Cas13 Knockdown in Human Cells
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32:52In this collaboration episode with NEB, we interview Dr. Neville Sanjana, a core faculty member at the New York Genome Center, about his recent publication in which chemically modified guide RNAs were used to enhance CRISPR-Cas13 knockdown in human cells.저자 Synthego
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GuidePost Ep. 20: Eben Kirksey, Human Futures and Gene Editing
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1:03:46Anthropologist and author Eben Kirksey discusses his interest in somatic and hereditary human genome editing, particularly the impact on patients and practitioners, the history of CCR5 gene editing, and recalls his exceptional reporting in China in the wake of the CRISPR babies scandal, all of which is included in his riveting book “The Mutant Proj…
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Kiana Aran Chats About her Nature Award and New Non-Profit
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41:09In this episode, we chat with Dr. Kiana Aran, the CSO of Cardea Bio and associate professor at Keck Graduate Institute, who recently won the Nature Research Award for Inspiring Women in Science. Dr. Aran talks about her experience being a nominee and award winner, her early days and scientific journey, and the launch of her new non-profit, Aran Neb…
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6 Women CRISPR Leaders Get Candid About Their Journeys to the Top
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1:02:44We chatted with six female leaders in the CRISPR—Alison van Eenennaam, Ph.D., Kiana Aran, Christina Trojel-Hansen, Ph.D., Laura Lambert, Ph.D., Elena Miñones Moyano, Ph.D., and Samantha Maragh, Ph.D.— about their professional journeys. Tune in to this episode for a candid and honest discussion on a broad range of topics, including their experiences…
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Jesse Boehm Discusses Tackling Rare Cancers Using CRISPR
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30:35In this CRISPR Cuts episode, Dr. Jesse Boehm, the Chief Scientific Officer of the Break Through Cancer Foundation and principal investigator at the Broad Institute, talks about his work on rare cancers. He also covers how CRISPR technology is transforming cancer research.저자 Synthego
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NIH Scientists Discuss the iNDI Project for Alzheimer's Disease Modeling
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37:14The Inducible Pluripotent Stem Cell Neurodegeneration Initiative (iNDI), an NIH effort, aims to standardize disease models for Alzheimer’s and related dementias. Hear the principal contributors, Dr. Michael E. Ward and Dr. Mark R. Cookson, scientists at the NIH, talk about the inception of the iNDI project, the challenges and opportunities, and the…
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Prime editing is a new genome engineering tool that emerged just a couple of years back. Right from the get-go, this technology made waves as a potential alternative to CRISPR. Now, the first comparative study in mice is out. Dr. Joe Miano, Professor at the Augusta University in Georgia, talks about their collaborative work comparing traditional CR…
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IGI Researchers Are Using CRISPR to Reduce Cyanide in Cassava
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26:30Did you know cassava can cause cyanide poisoning if it is not processed correctly and consumed with a protein-poor diet? In this episode, we chat with IGI researchers, Jess Lyons and Michael Gomez about their work on using CRISPR to reduce cyanide in cassava and improve its food safety.저자 Synthego
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GuidePost Ep. 19: David Liu, Precision Chemistry on DNA
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51:19The architect of base editing and prime editing, Harvard University chemist David R. Liu, recalls the genesis of the technology and discusses exciting preclinical results and potential future applications.{Sponsored by Pegasus Books}저자 The CRISPR Journal
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GuidePost Ep. 18: Kevin Davies, CRISPR Chronicler
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1:02:01In this podcast, Mendelspod host Theral Timpson interviews Kevin Davies about his latest book, "Editing Humanity: The CRISPR Revolution and the New Era of Genome Editing".{Episode Sponsored by Mendelspod}저자 The CRISPR Journal
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Kevin Davies Chats About His Latest Book "Editing Humanity"
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32:13Kevin Davies, the executive editor of The CRISPR Journal, has closely watched the genetics space evolve over the last decades. His expertise and experience were the perfect foundation for his latest book "Editing Humanity: The CRISPR Revolution and the New Era of Genome Editing." In this episode, Kevin discusses his motivation for the book, along w…
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In this episode, Michael Friend, CEO of Minority Coalition for Precision Medicine, discusses the lack of diversity in genome editing field and covers potential solutions for ensuring an inclusive future, particularly for black scientists.저자 Synthego
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CRISPR Forecast 2021 with Paul Dabrowski and Robert Deans
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17:49In this episode, Paul Dabrowski, CEO of Synthego, and Robert Deans, CSO of Synthego, discuss the CRISPR silver linings of 2020 and predict the directions and milestones for gene editing in 2021.저자 Synthego
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GuidePost Ep. 17: Dame Kay Davies, Guidance for Heritable Genome Editing
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38:07A conversation with Dame Kay Davies, University of Oxford geneticist and co-chair of the just-published international commission report on Hereditary Human Genome Editing (HHGE), which lays out a roadmap for if, when, and how we should proceed with embryo editing for couples with severe genetic diseases.…
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The COVID-19 pandemic is a unique situation for lab scientists, many of whose work has come to a standstill. Hamid Ghanadaan, CEO of Linus, discusses the impact of COVID-19 on science and the next steps for scientists, based on their survey of >1000 scientists.저자 Synthego
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Ryan Pawell Talks About Indee Labs’ CRISPR Delivery Technology for Affordable Immunotherapies
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12:59The mission of Indee Labs, a Berkeley biotech, is to deliver CRISPR reagents into cells using microfluidics for developing affordable cell and gene therapies in the future. We interviewed Ryan Pawell, Founder and CEO of Indee Labs, about the concept of using microfluidics for CRISPR delivery, their mission and ongoing projects, and the convergence …
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Making of a CRISPR Film: Behind the Scenes with Producers of Human Nature
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37:33What is the process to make a science film? In this episode, Sarah Goodwin and Elliot Kirschner, producers of Human Nature, a documentary on CRISPR, offer glimpses into making of the film.저자 Synthego
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Leading St. Jude's Genome Engineering Capabilities: A Chat with Shondra Miller
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10:13Shondra Miller shares her experience of starting a shared genome engineering resource at the St. Jude Children's Research Hospital. Learn more about her research projects and her views on the past, present, and future of the genome editing field in this podcast episode.저자 Synthego
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