This podcast is all about biochemistry tutorials.
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Become a Paid Subscriber: https://anchor.fm/dr-daniel-j-guerra/subscribe Become a Paid Subscriber: https://anchor.fm/dr-daniel-j-guerra/subscribe You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated. Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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This is a Urban Science, Hip Hop Chemistry, Trap Biochemistry, cutting edge and raw show on Nutrition in a format never before delivered. We are teach the Global Hip Hop community Nutrition, Biokinetics, Herbology, Healthy Living, Plant Based Lifestyles to a untapped audience by speaking in a tongue they are familiar with. We translate the "Scientific Jargon" into "Hood 101" with passion.
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Post comments, criticisms and questions you may have in Biochemistry to help this blog develop. Use this as often as you need. The more we communicate...the more you learn. This material assumes an advanced understanding of biology and chemistry as all of these videos are created after the actual lecture presentations on the topics. Send me your comments!!
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This is a feed of pages for Chem 102 General Organic and Biochemistry 2 Fall 2011
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Behind the Biochemistry is YOUR go-to podcast to engage with your inner scientific curiousty! On this podcast we will bust out the beakers to dive into the depths of topics such as cellular pathways that are essential to our daily lives & what happens when these are influenced via a variety of factors. We will include special guests and go and visit researchers and scientific entrepreneurs. It's time to have some fun, bust out the beakers, and find out what it BEHIND THE BIOCHEMISTRY!
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Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry c.6. 17April 2024.Authentic Biochemistry Podcast.Dr. Daniel J. Guerra.
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References Cold Spring Harb Perspect Med. 2020 Jun; 10(6): a034819 Proc Natl Acad Sci U S A. 2015 Jul 14; 112(28): 8661–8666 Blood. 2010 Jul 22; 116(3): 485–494. Haydn, FJ. 1793. Symphony No 101 D major "Die Uhr“. https://youtu.be/jK9EPZ3qdgU?si=GiCVxNOchDW0fKsb Croce, J. 1970. "Time in a Bottle". https://youtu.be/9h1davKgBYM?si=YhyPwAtno04oYBks --…
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T lymphocyte Membrane Biochemistry I. Immune Cell Biochemistry I c.5 Authentic Biochemistry 16April2024 Dr Daniel J. Guerra
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References Front. Immunol., 2022 Sec. Microbial Immunology Volume 12 Blood 2010. Volume 115, Issue 18, 6 May: 3708-3717 Seeger, P. 1959 . Performed by The Byrds "Turn Turn Turn" https://youtu.be/W4ga_M5Zdn4?si=ODKk_snS-5XHZvWP Copland, A. 1944. "Appalachian Spring. https://youtu.be/CJYVH_kZkOk?si=UUBet58ETg0PVUrB --- Send in a voice message: https:…
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Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry c.4. 15April 2024. Chemokine gradients and the membrane lipid raft. Authentic Biochemistry Podcast Dr. Daniel J. Guerra
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References FEBS J. 2018 Aug; 285(16): 2944–2971. Nature Reviews Immunology 2023. volume 23, pages 236–250. Angiogenesis. 2021; 24(4): 719–753. Front. Immunol. 2022 Sec. Microbial Immunology Volume 12 Camp, H. 1964. "Pride of Man". performed by Quicksilver Messenger Service. https://youtu.be/fG6A6G9uzsQ?si=tKMdQMVbpTn2x85D --- Send in a voice messag…
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Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry c.3. 14 April 2024 .Authentic Biochemistry Podcast.Dr. Daniel J. Guerra
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References Nat Rev Gastroenterol Hepatol. 2022 Jun;19(6):351-366 Drugs. 2016 Jul;76(11):1067-79. Front Immunol. 2021; 12: 613591 J Appl Microbiol. 2009. Jun;106(6):1908-18 Exp Cell Res. 2015 May 1; 333(2): 195–200. Mediators Inflamm. 2017; 2017: 4806541. Parsons, G. McQuinn,R. 1971. Pale Blue [ Byrds] Byrdmaniax lp. https://youtu.be/Mh3J7GqrdzY?si=…
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Immune Cell Biochemistry I.T lymphocyte Membrane Biochemistry c.2 Lipid mespmorph and radius assymetry direct Tcell membrane sterol and protein interdigitation that is altered by pressure via PV=nRT.
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References and simple equations PV = nRT where P is pressure (in atm), V isvolume (in liters), n is number of moles and T is temperature (in K); R is a constant and is equal to 0.08206 L atm/moleK. Molecular Shape including thickness(radius) of membrane curvature is v/al where v=volume,a=area per headgroup, and l=thickness of the hydrocarbon monola…
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Immune Cell Biochemistry I.T lymphocyte Membrane Biochemistry c.1. DJGPhD.11April24.Authentic Biochemistry Podcast
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References Front Immunol . 2021 Mar 10:12:613591. Guerra, D. 2020's. Membrane Biochemistry Lectures Crosby, D., Kantner, P., and Stills, S. 1968. "Wooden Ships" [Jefferson Airplane ] from Volunteers lp. https://youtu.be/ROBaoiJK0wc?si=ABsxa4m4AjjAwoms Mendelsshon, F. 1830. "The Hebrides Overture"-Fingal's Cave.OP26. https://youtu.be/MdQyN7MYSN8?si=…
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Biochemical Mosaic III. Coda. DJGPhD .09April24.Authentic Biochemistry Podcast
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References Guerra, D. 2024. The Mosaics I-III. https://podcasts.apple.com/us/podcast/authentic-biochemistry/id1454408625 Beethoven, LV. 1806. Violin Concerto D Major. Op 61. https://youtu.be/cokCgWPRZPg?si=pKKUsINChgI14PH9 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://po…
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Biochemical Mosaic III. c.14. From physical chemistry to the mechanisms of sphingomyelinase mediated inflammation: abrief dialectical accounting of research involving abiotic vs biological phenomena.
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References Guerra, D. 2024. Previous Lectures: Authentic Biochemistry. https://podcasts.apple.com/us/podcast/authentic-biochemistry/id1454408625 Waters, R.1973. "Eclipse" from [Dark Side of the Moon]; Pink Floyd lp. https://youtu.be/k0xGxnZFNYs?si=VrfYPQuXef41Drfm Holst, G. 1918. "The Planets" https://youtu.be/HP5xhyPn58U?si=IdN_iqJNvt_tjQKP --- Se…
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Biochemical Mosaic III.c.13. A priori intralocution of inflammasome genomic loci with stress phenomena immunoepigenetically resolves defensive inflammation. DJGPhD.6April24. Authentic Biochemistry.
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References Guerra, D. 2024 Previous Mosaic III lectures and content. https://podcasts.apple.com/us/podcast/authentic-biochemistry/id1454408625 Hayward, J. 1969. "Never Comes the Day" from Moody Blues lp. Threshold of a Dream. https://youtu.be/8u1zH11yqFQ?si=xtXp1SWm8rF1RdFS Mozart, WA.1785. String Quartet No. 19 in C Major, K. 465 https://youtu.be/…
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Biochemical Mosaic III. c12. A prolegomena to any future biochemical Instanence. Dr Daniel J. Guerra. 4April2024. Authentic Biochemistry Podcast
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Refernces Guerra, DJ. Inclusive non-extemporaneous reasoning on biochemical event ontologies. Jefferson, Blind Lemon 1927, Hunter-Garcia 1969 Jefferson's "I know You Rider" and "China Cat Sunflower" . Grateful Dead. Europe 72' LP. https://youtu.be/xCgZxrf8nrU?si=k7WGmY-fo_AjEip- Schmelzer, JH 1664. Violin Sonatas, "Romanesca". https://youtu.be/fB8G…
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Biochemical Mosaic III. Inflamasomes c.11 A Dialectical Event Ontological conciliantus contrarion perspective.DJGPhD.3April24.Authentic Biochemistry Podcast.
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REferences Guerra, DJ. 2024. Biochemical Mosaic III lectures. https://podcasts.apple.com/us/podcast/authentic-biochemistry/id1454408625 Dvorak, A. 1879. Romance in F minor, Op. 11, (B. 39). https://youtu.be/XZTeavJ9frA?si=18LFzAQ9FKfrQ_16 Dylan, R. 1975. "Tangled up in Blue" performed by Gerry Garcia Band (live;1977) https://youtu.be/8Aw7FW1Frjs?si…
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Biochemical Mosaic III.c.10 Atherogenesis and neointma formation are associated with sphingomyelinase membrane raft NOX aggregation during inflammasome activation.DJGPhD.2April24
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References J Lipid Res. 2022 Dec; 63(12): 100298. Mol Cells. 2020 Aug 31; 43(8): 749–762. Bach J.S. 1727. St Matthew Passion, BWV 244. https://www.youtube.com/live/3fP-rET0kFI?si=ZX-edMPg1wBA_5mh Squire, Chris. 1978. "You Can Be Saved" Yes. https://youtu.be/0TNzPHoVlz8?si=bFMp6w4T2SL6XxS4 --- Send in a voice message: https://podcasters.spotify.com/…
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Biochemical Mosaic III.c.9 Clinical associations of inflammasome mediated pathophysiology linked to epigenetic methylation patterning and DNA repair. DJGPhD.1April24.
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References Redox Biol. 2020 Apr; 31: 101482 Nat Rev Microbiol. 2009 Feb; 7(2): 99–109. J Neuroinflammation. 2019; 16: 236. Front Pharmacol. 2021; 12: 643254. Biber, H. 1676. "Passagalia" por solo violin https://youtu.be/sgcR183f8gA?si=ovfSbdg6WsfuIiTw McBroom, A. 1976. "The Rose" Conway Twitty https://youtu.be/cO59ITNCxzk?si=ueMmXtzMNH4YeQ_w Hunter…
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Biochemical Mosaic III.c.8. S. aureus clearance via dual pyroptosis and necroptosis salientsand the control over the hyperinflammatory axis of clinical disease. DJGPhD.31.3.24
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References Cell Reports 2016.Volume 16, Issue 8, 23 Pages 2219-2230 Front Immunol. 2020; 11: 621733 Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E961-E969 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support…
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Biochemical Mosaic III.c.7 Convergence of Inflammasome molecular patterning obtains PRR-like sequalae that are hypo-modified epigenetically in multple Human pathophysiologies
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References Int J Mol Sci. 2021 Jul; 22(14): 7580. Trends Biochem Sci. 2023 Apr;48(4):331-344 Immunology. 2020;159:142–155 Curr. Opin. Immunol. 2020;62:39–44. Nat. Rev. Mol. Cell Biol. 2019;20:569–570. Lennon-McCartney. 1963. "This Boy" https://youtu.be/lW5D7HpYhBU?si=mHyiFng3rd3pukob Lennon-McCartney.1966. "And your Bird Can Sing" https://youtu.be/…
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Biochemical Mosaic III. c.6. S auereus induced inflammasome activating pyroptosis circumvents immune clearance and ARDS pulmonary chronic activation share similar hyperinflammatory presentation.DJGPhD
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References Front Immunol. 2019; 10: 1309 Immunity. 2018 Sep 18; 49(3):413–426.e5. Front Immunol. 2020; 11: 621733 Infect Immun. 2013 Dec; 81(12): 4478–4489. Immunity. 2023 Nov 14;56(11):2523-2541.e8. Harrison, G. 1969. "Here Comes the Sun" Abbey Road Lp. Beatles https://youtu.be/GKdl-GCsNJ0?si=xUqwi3Q7Ne694ruD Mozart, WA. 1775. Violin Concerto No.3…
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Biochemical Mosaic III. c.5. Gal3 and NRLP3 inflammasome coordinate inflammation via IL-1Beta convertase activation that is associated with NAFLD and NASH and inhibition of ABCA1 cholesterol efflux.
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References Infect Immun. 2013 Dec; 81(12): 4478–4489 Cell Cycle. 2022; 21(11): 1121–1139. The Journal of Nutritional Biochem.2023.Volume 112, 109217 Lightfoot, G. 1964. "Early Morning Rain" https://youtu.be/ZFJ5Bj_put0?si=m1Ue7rFfk_ggSLR3 Simon ,P. 1968. "Old Friends" SImon and Garfunkle Bookends LP. https://youtu.be/7A76lTte8qE?si=rfk3Q6wTA6Nsiok7…
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Biochemical MosaicIII. C.4. My oppositional dialectic and episteme- metaphysical discourse on method+ Gal3 as proinflammatory lectin may not uniformly correlate with pathobiochemical events. DJGPhD.
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References Guerra, DJ. 2024. Uncollected writings. The Journal of Nutritional Biochemistry 2023. Volume 112, February. 109217 Walker, Cindy.1950 Blue Canadian Rockies. Cover "the Byrds"(1969). https://youtu.be/nzOHtU8Sb3c?si=5GAj7VPzIr7o0OO_t Heinichen J. D. 1711 (?)Concerto in A minor for violin https://youtu.be/V-E25Q-wjwc?si=bbWdZTNEUPGitY-S ---…
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Biochemical Mosaic III c.3. Bacterial glycosphingolipid mediated inflammasome activation and the Galectin:NLRP3 interaction pathophenocopy oxy-mtDNA TLR induction.DJGPhD.21.3.24
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References Front Immunol. 2020; 11: 591803 Am J Gastroenterol. 2004 Nov;99(11):2147-9. Biochem Biophys Res Commun. 2005 Dec 16;338(2):1031-6 Front Immunol. 2019 Jun 7;10:1309. FASEB J. 2021 May; 35(5): e21439. Hildegard von Bingen 1150.- "Canticles Of Ecstasy --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/me…
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Biochemical Mosaic III. C.2 A Non-canonical autophagic inhibition of NLRP3 inflammasome mediated inflammation in UVB-treated human keratinocytes.DJGPhD. 20.3.24.
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References Front Immunol. 2019 Jun 7;10:1309. JBC 2024 . March.Article in Press DOI:https://doi.org/10.1016/j.jbc.2024.107173 FASEB J. 2016 Dec;30(12):4202-4213. Nat Rev Gastroenterol Hepatol . 2020 Feb;17(2):93-110 Bach , JS. 1731. Piano Partita No. 2 In C Minor, BWV 826 https://youtu.be/f-OdOuNZciQ?si=AmFtC5CX3x2ndzdV Slade,Mann, and Rogers. 1975…
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Biochemical Mosaic III. C.1. Inflammasomes. DJGPhD.19.3.24 Authentic Biochemistry Podcast
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References Immunity 2022. Volume 55 Issue 8 Pages 1370-1385.e8 JBC 2024. March. Article in Press https://doi.org/10.1016/j.jbc.2024.107173 Schmelzer. J. H.1664 Sonatae unarum fidium. https://youtu.be/fB8G39y1uCA?si=ZMG2Zv9eKF3go0qR Hayward, J. 1967 "Tuesday Afternoon" Moody Blues https://youtu.be/fB8G39y1uCA?si=ZMG2Zv9eKF3go0qR Hayward, J. 1970 "Qu…
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Biochemical MosaicII.Book2.C.13.Dialectical event ontologies involving CNS plasmalogen and sphingolipid interlocution and the universality of Mozart and the Beatles. DJGPhD.17.3.24.Authentic Biochem.
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REferences Dr. Guerra. 2024.Previous Authentic Biochemistry Mosaic II lectures in the series Kant, I. 1790. Critique of Judgment. Mozart, WA. 1788. Sinfonie C-Dur KV 551 (»Jupiter«) https://youtu.be/6RbKWhr0o1c?si=xkt3QMG5aud__zLN Beatles. 1965. "Rubber Soul" https://youtu.be/kfSQkZuIx84?si=8QFvenLD4k8KLJD3 --- Send in a voice message: https://podc…
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Biochemical Mosaic II.Book 2. c.12 Adduced mTORC mediated glycerol-sphingolipid enzyme mRNA transcriptome association with Plasmalogen apodiction of myelination.DJGPhD.16.3.24
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References Developmental Cell 2022. Volume 57, Issue 6, 28 March Pages 691-706 Cell Rep. 2014 Feb 13; 6(3): 541–552. Dr Guerra: graduate lecture notes Mozart, WA 1791.Requiem in D Minor, K 626 https://youtu.be/YaH3zI0bYkM?si=X1yv50zY6nKTZmV9 Lennon/McCartney.1964 "I Don't Want to Spoil the Party" https://youtu.be/zqVDvLDLsjI?si=K1ve_5zJLZjqclsb ---…
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MosaicII,Bk.2.c.11 Squalene monooxygenase (SM) stabilization due to plasmalogen pathway fatty acid reductase deficiency promotes SM epoxidase alternate activity thus lowering24OHCHOL-LXR-myelination.
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References Dr Guerra-Graduate lipid biochemistry lectures Biochem J. 2022 Sep 30; 479(18): 1917–1940 Front Cell Dev Biol. 2022; 10: 946393. Nat Commun. 2019; 10: 97. Lennon-McCartney 1965. "Ive Just Seen a Face" https://youtu.be/m8LbJfC0SYM?si=gl_URu_yPTn9iZSd McShee, J./Traditional/Pentangle.1969 "Light Flight" https://youtu.be/2tyVezuUtCA?si=THxB…
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Biochemical Mosaic II. Book2. c.10.Plasmalogen mediated oxy vs epoxy sterol synthesis may control cns inflammation and myelination given acid-catalyzed transacetalization sequalae.DJGPhD.12March24
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References Front Cell Dev Biol. 2022; 10: 946393. Adv Exp Med Biol. 2024:1440:149-161 Mozart, WA..1786.Horn Concerto in E-flat major # 4 KV 495 https://youtu.be/MMjqU461WpI?si=o2OWIijoe-mbF-pM Sebastian, J. 1968 She's a Lady https://youtu.be/xyFdzevDOHg?si=wgmv5z_jGrtA9x7c --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-dani…
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Biochemical Mosaic II. Book2. c.9. Plasmalogen regulation of composite ruling over prescriptive organization of cellular-biochemical phenomena includes florid mediation of the CNS.DJGPhD.11MARCH2024.
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References Journal of Cell Science 2019.Vol.132(6), 223016. Brain Research Bulletin 2023.Volume 194, March. Pages 118-123. Beethoven, LV. 1806. Violin Concerto D major, Op. 61 https://youtu.be/_hXdjRYELGw?si=0q5_qJCZu_zAZWoE Berry, C. 1956. "Roll Over Beethoven" ; as performed by the Beatles 1963 on LP "With the Beatles" https://youtu.be/Hz5jXwOXgK…
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Biochemical Mosaic II.c.8 Cell death and CE-circ RNA vs.miRNA in Hepatocellular carcinoma: the spectre of AGPS et al. DJGPhD. 10March24.Authentic Biochemistry.
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References Cell Death Dis. 2020 Dec; 11(12): 1065. Genome Res. 2000 Oct; 10(10): 1445–1452. https://www.genecards.org/cgi-bin/carddisp.pl?gene=NIPBL Genes Dis. 2022 Jan; 9(1): 116–127 Schubert, F. 1824. Quartet 14 in D minor, D 810, "Death and the Maiden" https://youtu.be/XF_6vSlmm4w?si=CGTn3R6Tkn6LsMLv Browne,J. 1993. "Sky Blue and Black". https:/…
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Biochemical Mosaic II.c.7. Fatty acid desaturation and mole% PC/PE/PL/CER are elevated via circRNA in Medublastoma while AGPS increased circRNA's in thyroid cancer.DJGPhD.7Mar24. Authentic Biochem.
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References Acta Neuropathologica Communications 2023. volume 11, Article number: 38 Proc Natl Acad Sci U S A. 2020 Apr 7; 117(14): 7792–7798 Front Mol Biosci. 2022; 9: 925389. Front Cell Dev Biol. 2021; 9: 636838 Oncol Lett 2018. 15: 7889-7899. Saint-Saëns, C. 1886. Symphony No 3 in C minor, Op 78 https://youtu.be/ZWCZq33BrOo?si=8hQ01E9jfp0eU07o Wi…
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Biochemical Mosaic II.c.6 Meduloblastoma is linked to plasmalogen and circ RNA phenomena that are pathophenocopied in other cancers. DJGPhD.5.Mar24.Authentic Biochemistry
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References Acta Neuropathologica Communications 2023. volume 11, Article number: 38 Proc Natl Acad Sci U S A. 2020 Apr 7; 117(14): 7792–7798. Int J Med Sci. 2022; 19(6): 975–985 Nature Communications 2022. volume 13, Article number: 1508 Lassus. O. 1578. Requiem - Missa pro defunctis (4vv) : Offertorium https://youtu.be/UXY4hxCvu7M?si=lcM_lw11lbPWr…
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Biochemical Mosaic II. c.5 Peroxisomal plasmalogen biosynthesis may regulate transcriptomic and proteomic sequalae to plasmamembrane mediated signal transduction. DJGPhD.4March24.
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References Front Physiol. 2021; 12: 730829. Non-coding RNA Investig 2017. 1:5. Genome Biology 2011. volume 12, Article number: 236 RNA Biol . 2021 Nov 12;18(sup2):574-585. Hunter. R. 1975. "Cruel White Water" https://youtu.be/T-oBD3F74Nk?si=zsrEBN0JKan_FXdH --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/mess…
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Biochemical Mosaic II. c.4. Peroxisomal biogenesis and AGPS-mediated plasmalogen synthesis involve circular RNA species that alter microRNA and mRNA expression in human cancers. DJGPhD.3MAR24.
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References Genome Res. 2004 Nov;14(11): 2245–2252. Int J Med Sci. 2022; 19(6): 975–985. Oncol Lett. 2018 May; 15(5): 7889–7899. Cell Death Dis. 2020 Dec; 11(12): 1065. RNA Biol . 2021 Nov 12;18(sup2):574-585 Bach, J Christian. 1775. Sinfonie Concertante https://youtu.be/S8NPgouJ5uk?si=_azSWNelNFRA2ai5 --- Send in a voice message: https://podcasters…
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Saturday Night Authentic Biochemistry The Agentic operator as metaphysical metaphor in metabolic regulation. DJGPhD.2March 2024.
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References Dr Guerra Archives: Graduate Biochemistry Lecture notes and syntheses Simon, P. 1969. The Boxer. https://youtu.be/l3LFML_pxlY?si=Nv5-mSzRu6fHP8Sr Boccherini, L. 1760. 7. Cellokonzert https://youtu.be/NSU6Ylxaobs?si=PZW0S3mWl25RwnE2 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this…
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Biochemical Mosaic II. c.3 Plasmalogen metabolism is coherently associated with peroxisomal integrity and replication. DJGPhD.01March 2024 Authentic Biochemistry.
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References Oncol Lett. 2018 May; 15(5): 7889–7899 Nat Genet. 1997 Apr;15(4):369-76 Biochim Biophys Acta Mol Cell Res. 2020 Feb;1867(2):118609 Protein Cell 2018. 9, 196–206 Brain Research Bulletin 2023. 194: 118–123 The Moody Blues. 1968. "In Search of the Lost Chord" https://youtu.be/k5UdP-SFNgY?si=zDboUgA2LDi3E7m1 --- Send in a voice message: http…
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Biochemical Mosaic II. C.2. Plasmalogen and PAF biosynthesis in relation to glycerol lipid and intermediary subcellular metabolism.DJGPhD.27.2.24
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References Guerra: graduate biochemistry lectures Chopin, F. 1830. Nocturne E Flat Major Op.9 No.2 https://youtu.be/tV5U8kVYS88?si=MKxfguVRI6hhQeMO Winwood, Wood and Capaldi 1967. Dear Mr Fantasy. Traffic. https://youtu.be/sS_eHdqcrM8?si=95X9RWJD2Q4w456S --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message…
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Biochemical Mosaic II. Plasmalogens & other ether lipids. c.1 DJGPhD.26.2.24. Authentic Biochemistry Podcast
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References Cell Metab. 2014 Mar 4; 19(3): 380–392. Protein Cell 2018. 9, 196–206. Membranes 2023, 13(9), 764. Debussy , C. (. 1890;1905) Clair de lune. https://youtu.be/6zzWnxuQPWI?si=gcEAKpbgc9xO8esf Morricone. E. 1968. "Once Upon a Time in the West" https://youtu.be/j5eQ9UTmDLo?si=-eUjJ1s9hAd6fpwz Schubert, F. 1825. Ave Maria https://youtu.be/2H5…
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A Dialectical Interlocution with Mozart. DJGPhD.24.2.24 Authentic Biochemistry Podcast
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References Mozart.WA 1782. Fantasie in D minor. K.397 https://youtu.be/OYiz_u0tDwM?si=0dP736rTEkb4sauL 1785.Piano Concerto 22 in E flat Major.K.482 https://youtu.be/EJYPnrYNt8A?si=VqgS-PNw2bnbIFBj 1788.Divertimento in E♭ major, K. 563. https://youtu.be/2N4hHhTu4pw?si=p-VwHTTOK5ixFWfk 1787. Eine kleine Nachtmusik, K. 525. https://youtu.be/156u4nV2uG…
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Biochemical Mosaic I. CODA. Membrane lipids function as biosensors for pKa's of phosphonoester anionic charge density with polybasic protein domains to mediate communication including transcription.
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References J Biol Chem 2017 292: 20481. Nature Cell Biology 2019. volume 21, pages 338–347 Rossini.G. 1829. William Tell Overture. https://youtu.be/z7Tj2SzToHI?si=QUXkj3NzqF17Zq60 Vivaldi, A. 1712. Concerto in D Major. RV 212. https://youtu.be/l21_9KKy1Pg?si=9HSMxRj7huJF1B8j --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-da…
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Biochemical MosaicI.c.13 Phosphatidic acid as key lipid intermediary of membrane secretion signalling and cellular intracommunication via kinase cascade and transcriptional regulation.DJGPhD.22.2.24
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References Biomedicines 2023, 11(7), 1804 BMC Biology. 2011. 9:85 Cancer Res. 2011 Jan 15;71(2):293-7. FEBS Lett.2019.593.17:2428-2451 Verdi, G. 1841. Nabucco Overture https://youtu.be/OseGETWEnCo?si=LhiIQV-N0-_Z_s-s Lennon&McCartney. 1966 "For No One". Beatles: Revolver. https://youtu.be/sep5E3ssXLQ?si=WLtMrP-Xq279qZXl --- Send in a voice message:…
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Biochemical Mosaic I. c.12. The porosomal secretory system requires anioic lipids including phosphatidic acid. DJGPhD.21.2.24
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Dr. Guerra: membrane graduate biochemistry lecture notes J Cell Mol Med . 2015 Jul;19(7):1427-40 Langmuir, 2018, 34 (1), pp 530–539 Elgar, E. 1900. The Dream of Gerontius https://youtu.be/rnwmVypRY-g?si=CxF8tZrfRR-uWdhn --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podca…
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Biochemical Mosaic I.c.11. Glycerolipid metabolism coupled to mTORC1 enzyme phosphorylation necessarily involves a complete analysis of membrane lipid molecular species distribution.DJGPhD.20.2.24
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References Nature . 2019 Nov;575(7782):361-365. Adv Biol Regul. 2017 May:64:39-48 J Biol Chem. 2013 Apr 5; 288(14): 9933–9945 Redox Biology.2017. Volume 11, April. Pages 622-630 Biochim Biophys Acta. 2011 Jun;1811(6):377-85 Dr Guerra: lipid lectures archives Schubert, F. 1816. Symphony #5 https://youtu.be/OHkot1TmvZU?si=uYtQfxUegl3KrkRK Newman, L D…
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Biochemical Mosaic I c.10. Is PE depletion reversed by mTORC1 phosphorylation of LIPIN1 or is DAG authentically activating CCT via membrane association thus obtaining robust PL synthesis? DJGPhD.
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References Biochim Biophys Acta. 2011 Jun;1811(6):377-85 Am J Physiol Lung Cell Mol Physiol 2001. 281: L98–L107. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1997. Volume 1348, Issues 1–2, 4 Pages 79-90. Am J Physiol Lung Cell Mol Physiol 2001. Volume 281. Issue 1July Pages L108-L118 JBC 1991. Volume 266, Issue 36, 25 December.…
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Biochemical Mosaic I. c.9 Increased inner mitochondrial membrane PE from PS decarboxylase decreases protease mediated degradation of phospholipid transfer proteins thus maintaining fusion potency.
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References PLoS Biol 2014. 12(10): e1001969 J Biol Chem. 2012 May18;287(21):17589-17597 J Biol Chem. 2012 Nov 23;287(48):40131-9 Nature 2019. volume 575, pages 361–365 Alleluia: Lobet den Herren. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/sh…
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Biochemical Mosaic I PA-phosphatase c.8. Membrane fusion and the dynamics of mitochondrial reduction vs. proliferation; the PA phosphatase in lipid metabolism. DJGPhD. 16.2.24 Authentic Biochemistry
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References Dr Guerra membrane lectures archive FASEB J. 2021 Jun; 35(6): e21620. Vivaldi, A. 1711. Concerto for 4 Violins in B minor RV 580 https://youtu.be/SY3Kxf7ZTeI?si=JLQXMtK06Y6Yfu_k --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-d…
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Biochemical Mosaic I. Phosphatidic acid Phosphatase. c.7. Mutational reversal of IDH1 leads to NADPH depletion concomitant with potent anti-PHD enantiomeric 2-hydroxyglutarate obtaining pseudohypoxia.
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ReferencesFEMS Microbiol Rev.1998. Oct;22(4):255-75 Discoveries(Craiova). 2017 Jul-Sep; 5(3): e77. J Cell Mol Med. 2015 Jul; 19(7): 1427–1440. Oncogene. 2017 Mar 23; 36(12): 1607–1618. Bach, JS. 1742. Kunst der Fuge , BWV 1080; Marta Czech https://youtu.be/p1Sq1HOYglU?si=2GMF7kf3dLW4rr2O Lennon and MCartney.1968. "Martha my Dear" https://youtu.be/R…
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Biochemical Mosaic I. The PA phosphatase c.6. Alteration of the TCA pathway intermediates and hypoxia/nutrient deficiency control HIF1α stability indirectly regulating IMM protein and lipid turnover.
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References Front. Oncol. 2017. 26 November.V.7. Oncogene. 2017 Mar 23; 36(12): 1607–1618. Schubert, F. 1819 Piano Quintet in A major, D. 667/ "Trout" https://youtu.be/syod5rkFdNY?si=5F3rexiou7dTifYg Hunter, R., Garcia , J. 1970 "Ripple" https://youtu.be/xofhZx9eWUQ?si=tpOAMzyW5qUy01P_ --- Send in a voice message: https://podcasters.spotify.com/pod/…
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The Biochemical Mosaic I. Phosphatidic Acid Phosphatase c.5. Tumor cells adapt bioenergetic fuel economy toward cell immortalization via re-crafting of mitochondrial IM lipid speciation.DJGPhD.12Feb24
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References Cell Metabolism 2019. 30: 720–734 Nature 2019. 575: 361–365 Squire, C. 1978. "Onward" Yes. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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Biochemical Mosaic I. Phosphatidic Acid Phosphatase c.4 GLN utilization and an IMM protease regulate mitochondrial involvement in cancer growth. DJGPhD. Authentic Biochemistry 10Feb24
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References Cell Death & Disease 2022. volume 13.Article number: 444. Nature 2019. volume 575, pages 361–365 Scientific Reports 2021. volume 11, Article number: 16512 Experimental & Molecular Medicine 2020. volume 52, pages 1496–1516 Mozart, WA. 1788. Piano Trio in G Major, KV 564 https://youtu.be/oOEuVtr8sF0?si=3-9RK1XkGkSWne7I --- Send in a voice …
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Biochemical Mosaic Event Ontologies I. Phosphatidic Acid Phosphatase. c.3 Indirect consequences of mitochondrial proteomic variation potentially obtains GLN-linked Warburg glycolysis preventing ROS.
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References Cell Metabolism 2019. 30, 720–734 Redox Biology2013. Volume 1, Issue 1: 427-432 Nature 2019. volume 575. 361–365Mozart, WA, 1779.Sinfonia Concertante Es-Dur, KV 364 https://youtu.be/iGDfj5uM_qA?si=bKNmj1r1o9zSMaA7 Lennon-McCartney. 1966. "Im Only Sleeping" https://youtu.be/sAG3m3p9UeI?si=oT6Luxnc6eFS_pEq --- Send in a voice message: http…
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Biochemical Mosaic Event Ontologies I. Phosphatidic Acid Phosphatase. Autophagy commitment is linked to mTORC1 v. AMPK oppostional kinase networks maintaining proteostasis and lipid homeostasis.DJGPhD
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References Nature 2019.volume 575, pages 361–365 Cells 2022, 11(21), 3339 Guerra: Polypeptide, endomembranous lipid homeostasis, and bioenergetics lecture archives. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support…
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Biochemical Mosaic Event Ontologies I. Phosphatidic Acid Phosphatase. Prologomena c.1.
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References J Cell Biol. 2014 Mar 17; 204(6):919–929 Nature 2019. Volume 575, pages 361–365. Redox Biology 2013. Volume 1, Issue 1. Pages 427-432. Madrigali Guerrieri et Amorosi {Libro Ottavo} https://youtu.be/2TjkhWARBVE?si=-ZI_kVa5WZX_9qnB --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this p…
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