TWiV 1170: Clinical update with Dr. Daniel Griffin

This Week in Virology

In his weekly clinical update, Dr. Griffin dives into H5N1/influenza and RSV circulation in the US, whether or not H5N1 is “adapting” for human-human transmission, why drinking raw milk may NOT be the best idea despite RFK Jr endorsement, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how if I encounter no one I can infect no one, the efficacy of COVID-19 boosters, how vaccines are the ‘seat belt’ of public health, the results of two PLACEBO control studies assessing antiviral therapy for COVID-19, where to find PEMGARDA, susceptibility of neurological complications in young to middle-aged adults and how discussing the origins of the pandemic and rise of scientific harassment will allow you to avoid a political conversation around your Thanksgiving day table, the interplay between transmission and immunity for virus spread and who to call if you do get sick this holiday. Happy Thanksgiving!

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Links for this episode

• Influenza weekly surveillance report: cliff notes (CDC FluView)
• US respiratory virus activity (CDC Respiratory Illnesses)
• RSV-Network (CDC Respiratory Syncytial virus Infection)
• In case you missed, US respiratory virus activity (CDC Respiratory Illnesses)
• Adaptation of H5N1 to humans…..sequence analysis (Nature)
• Favoring human transmission for H5N1 ?(Youtube: medcram)
• From 2022: unprecedented bird flu outbreaks sweeping the world…..and we are still talking about it? (Nature)
• What children get flu: First child in US infected with H5N1 (CDC Newsroom)
• Bird flu detected in raw milk……but RFK at HHS says it is safe? (NBC News)
• COVID-19 deaths (CDC)
• COVID-19 national and regional trends (CDC)
• Waste water scan for 11 pathogens (WastewaterSCan)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• If I see no one in my house, household Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmission is reduced! (CID)
• Updated boosters conferred protection against SARS-CoV-2 infection and emergency visits/hospitalizations during a JN.1 variant wave(CID)
• Provisional COVID-19 mortality (CDC National Center for Health Statistics)
• Influenza, RSV and COVID-19 vaccine in nursing home residents (CDC MMWR)
• Vaccines are the seat belts of public health (TRID)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• Fusion center near you….if in NY (Prime Fusions)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Effectiveness of molnupiravir against 30-day mortality among 74 541 SARS-CoV-2 positive patients (OFID)
• Sustained Recovery Among Outpatients With COVID-19 Receiving Montelukast vs Placebo(JAMA Network Open)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Remdesivir for treatment of COVID-19 requiring oxygen support (CID)
• Daniel Griffin’s evidence based medical practices for long COVID (OFID)
• Neurologic manifestations of long COVID disproportionately affect young and middle-aged Adults (Annals on Neurology)
• To review, three score and two months ago, the WHO brought for on this planet, the declaration of SARS-CoV-2/COVID-19….
• How nature began a pandemic (microbeTV)
• Bullying within the origin scientific discourse……by those at Rutgers (Science)
• Scientific harassment on the rise (Science)
• Doxing :The de-identified of the de-identified (Wikipedia)
• Harassment survey (Science)
• The harm of factless hypotheses (mSphere)
• In summary, the era of harm: factless theories (microbeTV)
• Stay inside: risk of SARS-CoV-2 transmission in community indoor settings (JID)
• Lower levels of household transmission of SARS-CoV-2 VOC Omicron compared to Wild-type: an interplay between transmissibility and immune status (JID)
• Long COVID hotline (Columbia : Columbia University Irving Medical Center)
• Letters read on TWiV 1170
• Dr. Griffin’s COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [e-mail]