Ep. 37: “Co-Evolution of the Human Microbiome” Featuring Drs. Ruth Ley and Sara Clasen

The Immunology Podcast

Guest:

Dr. Ruth Ley is Managing Director of the Max Planck Institute for Biology Tübingen and Director of the Department of Microbiome Science. Dr. Sara Clasen is a postdoctoral fellow in the same lab. Together, they’re interested in the co-evolution of humans with their microbiomes. They use basic science to investigate the evolutionary history of gut microbes, how they have adapted to life inside humans, and how they affect human biology and health. More recently, they published a pre-print on the silent recognition of flagellins from human gut commensal bacteria by TLR5.

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The Immunology Science Round Up

Hair Follicles and Mites – Scientists show that innate type 2 immunity controls hair follicle commensalism by Domedex mites.

The Search for a Shared Neoantigen – Using quantitative immunopeptidomics, researchers have identified a tumor stroma-specific target for T cell therapy.

Gut Microbes Surf the IgA Cycle – New research suggests that circadian networks comprising intestinal IgA, diet, and microbiota converge to align circadian biology in the intestine and to ensure host-microbial mutualism.

A New Way to Make CAR-T Cells – Researchers have successfully generated non-viral, gene-specific targeted CAR-T cells through CRISPR-Cas9.

Images courtesy of Drs. Ruth Ley and Sara Clasen

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