Human herpesvirus 6 and Hashimoto’s Disease

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Manage episode 262995135 series 2687172
Player FM과 저희 커뮤니티의 Dr. Nikolas Hedberg, D.C. - Functional Medicine Researcher, Dr. Nikolas Hedberg, and D.C. - Functional Medicine Researcher 콘텐츠는 모두 원 저작자에게 속하며 Player FM이 아닌 작가가 저작권을 갖습니다. 오디오는 해당 서버에서 직접 스트리밍 됩니다. 구독 버튼을 눌러 Player FM에서 업데이트 현황을 확인하세요. 혹은 다른 팟캐스트 앱에서 URL을 불러오세요.
Human herpesvirus 6 or HHV-6, is a herpes virus just like Epstein-Barr Virus, Cytomegalovirus, Chicken pox (varicella zoster), HHV-7, HHV-8 and Herpes simplex 1 and 2. There are two types of this virus including HHV-6A and HHV-6B. 100% of human beings get infected with HHV-6B by the age of three which results in fever, diarrhea and a rash called roseola. In rare cases it can cause seizures and encephalitis. There are many infection connections to autoimmune diseases like Hashimoto's disease and in this article I'll cover the connection between HHV-6 and Hashimoto's disease. Less is known about HHV-6A which was found in a small study in 50% of adults. HHV-6A is said to be the most problematic of the two types and it is the type found inside the thyroid glands of some people with Hashimoto’s thyroiditis. Just like other herpes viruses, HHV-6 can reactivate (occurs in the thyroid gland, GI tract, brain, heart, kidneys, uterus, and lungs) later in life when the immune system is compromised resulting in a variety of conditions including: Hashimoto’s thyroiditis Sjogren's syndrome Lupus Rheumatoid arthritis Sarcoidosis Guillan-Barre Multiple Sclerosis Infertility Chronic fatigue syndrome Fibromyalgia HIV progression to AIDS Epilepsy Seizures Immune suppression Certain types of cancer Kidney, liver, lung disease Heart disease Encephalitis Colitis Transplant recipient issues Bone marrow suppression Autoimmune hepatitis What is the link between HHV-6 and Hashimoto’s disease? Here are some studies supporting the connection between HHV-6 and Hashimoto's disease: Rizzo et al. in 2016 found a direct connection among natural killer cell activation, thyroid antibodies, and HHV-6 in patients with Hashimoto's disease. This study found that the HHV-6 virus causes an increase in natural killer cells against the virus which causes an ongoing inflammatory process in the thyroid gland that correlates with thyroid peroxidase and anti-thyroglobulin antibodies. This means that an active HHV-6 infection in the thyroid gland drives the elevation of thyroid antibodies and increases inflammation in the gland resulting in increased damage to thyroid tissue. A study published in 2012 entitled "Virologic and Immunologic Evidence Supporting an Association between HHV-6 and Hashimoto's Thyroiditis" by Caselli et al. found that a high percentage of patients in the study with Hashimoto’s disease have active HHV-6A infections inside the thyroid gland. This increases inflammation in the thyroid gland since the immune system is concerned about Human herpesvirus 6 and due to antibodies against the thyroid gland. A follow-up study by Caselli et al. in 2017 entitled "HHV-6A in vitro infection of thyrocytes and T cells alters the expression of miRNA associated to autoimmune thyroiditis" also found a connection between HHV-6 and Hashimoto's disease. Sultanova et al. in their 2017 paper entitled "Association of active human herpesvirus-6 (HHV-6) infection with autoimmune thyroid gland diseases" found a statistically significant higher level of persistent HHV-6 infection in those with Hashimoto's disease compared to the control group. They also biopsied thyroid tissue of patients with Hashimoto's disease compared to a control group without Hashimoto's disease, and they found a statistically significant higher level of HHV-6 in those with Hashimoto's disease compared to the control group (18/44 (41%) vs. 1/17 (6%)). Seyyedi et al. in their 2019 paper entitled "Human herpesvirus 6A active infection in patients with autoimmune Hashimoto's thyroiditis" consisting of 242 patients found 57 out of 151 (38%) of patients with Hashimoto's disease had active HHV-6A infections. 5 out of 59 (8%) patients with non-autoimmune thyroid disorders had active HHV-6A infections. And 0 out of 32 (0%) patients with normal thyroid function had active HHV-6A infections. Why does it reactivate in some people?

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