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Manage episode 262995133 series 2687172
Player FM과 저희 커뮤니티의 Dr. Nikolas Hedberg, D.C. - Functional Medicine Researcher, Dr. Nikolas Hedberg, and D.C. - Functional Medicine Researcher 콘텐츠는 모두 원 저작자에게 속하며 Player FM이 아닌 작가가 저작권을 갖습니다. 오디오는 해당 서버에서 직접 스트리밍 됩니다. 구독 버튼을 눌러 Player FM에서 업데이트 현황을 확인하세요. 혹은 다른 팟캐스트 앱에서 URL을 불러오세요.
There is a new exciting paper on the connection between eradicating the intestinal parasite Blasctocystis hominis and improving Hashimoto’s disease. I previously reported this infection connection in a case study which revealed an individual with Hashimoto’s disease getting better after eradicating Blastocystis hominis. Case studies aren’t the strongest scientific proof of a particular therapy but now we have an excellent paper with three research groups including a much-needed control group. This paper is entitled, “Improving Hashimoto’s thyroiditis by eradicating Blastocystis hominis: Relation to IL-17” published in the journal Therapeutic Advances in Endocrinology and Metabolism by El-Zawawy et al. The author’s begin by pointing out a very important fact that Hashimoto’s thyroiditis was once thought to be a TH1-mediated disease but once TH17 cells were discovered it became clear that it is a TH17-mediated disease. TH17 cells drive autoimmunity through production of the cytokine IL-17. Blastocystis hominis is the most common intestinal parasite in humans and most individuals never get any symptoms. This parasite is opportunistic however so if your gut or immune system becomes compromised, it can multiply and cause gut symptoms such as constipation and diarrhea, joint pain, drive autoimmunity and a host of other health problems. Blastocystis hominis has a prevalence of 1.6% to 16% in developed countries and up to 60% in developing countries. You can get this parasite from contaminated food or water. How was this study done on Hashimoto's Thyroiditis and Blastocystis hominis? 60 patients aged 19-57 with 19 females and 1 male in each group. Group 1: 20 patients recently diagnosed with Hashimoto’s thyroiditis without Blastocystis hominis infection. Group 2: 20 patients recently diagnosed with Hashimoto’s thyroiditis with confirmed Blastocystis hominis infection. Group 3: 20 healthy subjects without Hashimoto’s thyroiditis and not infected with Blastocystis hominis infection. All subjects in group 1 and 2 had a history of fatigue. 9 patients in group 1 and 7 patients in group 2 had a history of constipation. 6 patients in group 2 had a history of diarrhea. Interestingly, all subjects in group 2 who were infected with Blastocystis hominis had significantly higher blood pressure than the other 2 non-infected groups. The following tests were done on all subjects: Free T4 Free T3 TSH Anti TPO antibodies IL-17 Stool analysis CBC (complete blood count) ALT and AST (liver enzymes) Albumin Bilirubin Cholesterol Triglycerides BUN (blood urea nitrogen) Creatinine Group 2 which was infected with Blastocystis hominis was treated with the medication Nanazoxid for 3 days to eradicate the parasite and then retested 6 weeks later. What were the study results? TSH levels were higher in groups 1 and 2 compared to the healthy group 3 as expected. Free T4 was lower in group 1 compared to group 3 however group 2 did not have lower levels than group 3. Free T3 was significantly lower in group 2 compared to group 3. Free T3 levels in group 1 were not significantly different than the control group. TPO antibodies were the same between group 1 and group 2. Group 1 and group 2 had significantly higher levels of IL-17 compared to the healthy control group. However, group 2 had significantly higher levels of IL-17 compared to group 1 because group 2 was infected with Blastocystis hominis. They also found that high levels of IL-17 correlated with higher levels of anti-TPO antibodies and lower levels of Free T3. What happened to the patients treated for Blastocysis hominis? 10 patients in group 2 reported improvement in fatigue and 5 patients had improved constipation. Diarrhea completely resolved in all 6 patients. Blood pressure in group 2 which was significantly higher before treatment did not change after treatment.