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Manage episode 262995156 series 2687172
Player FM과 저희 커뮤니티의 Dr. Nikolas Hedberg, D.C. - Functional Medicine Researcher, Dr. Nikolas Hedberg, and D.C. - Functional Medicine Researcher 콘텐츠는 모두 원 저작자에게 속하며 Player FM이 아닌 작가가 저작권을 갖습니다. 오디오는 해당 서버에서 직접 스트리밍 됩니다. 구독 버튼을 눌러 Player FM에서 업데이트 현황을 확인하세요. 혹은 다른 팟캐스트 앱에서 URL을 불러오세요.
Our discussion today revolves around a microscopic parasite called Blastocystis hominis, a case of hives and Hashimoto’s disease! The case report was published in 2015 in The Journal of Infection in Developing Countries. The report was entitled, “Eradication of Blastocystis hominis prevents the development of symptomatic Hashimoto’s thyroiditis: a case report. The case involved a singular subject who was suffering from chronic urticaria (hives), angioedema (skin swelling) and overly soft stools who also showed signs of Hashimoto’s disease. But before we delve into more details, let me provide you with some basic background information. Background on Blastocystis Hominis Blastocystis hominis is the most common protozoan parasite in humans with incidence between 5-75% depending on the country's level of development. In the past, it had been considered as a non-pathogenic parasite. However, studies by the research teams of Katsarou-Katsari, et al. (2008), Valsecchi et al. (2004) and Vogelberg et al. (2010) showed that Blastocystis hominis infection is associated with chronic urticaria. What is urticaria? In general, urticaria is a very common skin disorder that can have immune, non-immune or idiopathic causes. It appears as swollen, pale red bumps or plaques. When the skin lesions appear within a six-week period, the patient would be described as having a case of acute urticaria. Anything longer than six weeks, however, is clinically defined as chronic urticaria. You may be wondering at this point what a parasite and a skin condition have to do with Hashimoto’s disease. Existing research has revealed that chronic urticaria and the presence of anti-thyroid antibodies, or autoimmune thyroid disease, have some kind of association with reported prevalence from 12-29%. How does the parasite Blastocystis Hominis trigger Hashimoto's disease? A study conducted in 2004 by Pasqui et al. and a clinical review published in 2008 by Tan discussed how Blastocystis hominis activates specific Th2 immune cells that produce interleukins which are proteins that are important in the immune response. The researchers in this study identified a deficiency of studies on the pathogenic role of Blastocystis hominis in the direct development of autoimmune disease. They then proposed that there may be a connection between this parasite and the onset of Hashimoto’s disease. The Case Report on Blastocystis Hominis and Hashimoto's Disease The 49-year old subject suffering from chronic urticaria, angioedema and soft stool consistency was found to have Hashimoto’s thyroiditis even though he had never exhibited symptoms of this disease before. The patient’s physician had already prescribed an anti-histamine which typically resolves hives. The patient also underwent a restrictive diet which did not contain any established allergens such as fish, cheese, dairy products, nuts, wild animal meat, vine, artificially colored products, etc.). That did not resolve the urticaria. What Lab Tests Were Done? The patient then endured quite a battery of tests. Those included: Blood count Differential blood count Glucose Urea Creatinine Minerals C-reactive protein …and over 25 other tests. The patient even had an ultrasound of the abdomen which looked normal. In addition, the prick skin test was performed for 13 standard inhalatory and 15 nutritive antigens. Everything was in reference range which indicated that nothing was amiss there. Next, stool cultures for the presence of parasites Blastocystis hominis were isolated on three separate occasions. The plan was then to focus on the thyroid and autoimmunity as hypothesized by the researchers so the following lab tests were done: IgE (immune system antibodies) TSH FT3 FT4 Anti-thyroglobulin (Anti-TG) Anti-thyroperoxidase (Anti-TPO) What Did the Thyroid Lab Tests Reveal? Total IgE was slightly elevated