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The Role of Small RNAs in Transgenerational Inheritance in C. elegans (Oded Rechavi)
저장한 시리즈 ("피드 비활성화" status)
When? This feed was archived on September 02, 2022 22:36 (). Last successful fetch was on July 28, 2022 16:40 ()
Why? 피드 비활성화 status. 잠시 서버에 문제가 발생해 팟캐스트를 불러오지 못합니다.
What now? You might be able to find a more up-to-date version using the search function. This series will no longer be checked for updates. If you believe this to be in error, please check if the publisher's feed link below is valid and contact support to request the feed be restored or if you have any other concerns about this.
Manage episode 275046122 series 2369335
In this episode of the Epigenetics Podcast, we caught up with Dr. Oded Rechavi, Professor at the University of Tel Aviv, to talk about his work on the role of small RNAs in transgenerational inheritance in C. elegans.
The most prominent example of transgenerational inheritance is the Dutch famine of 1944 during World War II. Effects of this famine could be observed in the grandchildren of people that lived through this hunger winter, but the molecular mechanisms involved remain largely unknown. The guest of this podcast episode, Dr. Rechavi, has taken on the challenge to unravel parts of this puzzle by studying transgenerational epigenetics in C. elegans.
It was already known that small RNA molecules could play a role in passing on information from one generation to the next, but it was not clear what exactly was being inherited. Was it RNAs? Or chromatin modifications? Or something else?
Dr. Rechavi made several important discoveries in his journey to answer these questions. He started out by showing that RNAi provides an antiviral protection mechanism in C. elegans that can be passed on over multiple generations. He then went on to show that starvation in one generation leads to changes in the lifespan of future generations, and investigate how long this memory could last. Simple dilution of the parental RNA in future generations could not be the answer because the inherited phenotypes lasted much longer than would be possible if this were the case. This led Dr. Rechavi to the discovery that small RNAs were amplified in each generation, and the effect of a stimulus could affect multiple generations. More recently, Dr. Rechavi and his team studied the interplay of neurons and the germ line and how information can be passed on from the brain to the germ line.
In this interview, we cover how Dr. Rechavi chose C. elegans as a model organism, discuss his first major discoveries in the field of transgenerational effects of starvation, and what role epigenetic factors play in this process.
References
- Oded Rechavi, Gregory Minevich, Oliver Hobert (2011) Transgenerational Inheritance of an Acquired Small RNA-Based Antiviral Response in C. elegans (Cell) DOI: 10.1016/j.cell.2011.10.042
- Oded Rechavi, Leah Houri-Ze’evi, … Oliver Hobert (2014) Starvation-induced transgenerational inheritance of small RNAs in C. elegans (Cell) DOI: 10.1016/j.cell.2014.06.020
- Leah Houri-Ze’evi, Yael Korem, … Oded Rechavi (2016) A Tunable Mechanism Determines the Duration of the Transgenerational Small RNA Inheritance in C. elegans (Cell) DOI: 10.1016/j.cell.2016.02.057
- Itamar Lev, Uri Seroussi, … Oded Rechavi (2017) MET-2-Dependent H3K9 Methylation Suppresses Transgenerational Small RNA Inheritance (Current biology: CB) DOI: 10.1016/j.cub.2017.03.008
- Leah Houri-Zeevi, Yael Korem Kohanim, … Oded Rechavi (2020) Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans (Cell) DOI: 10.1016/j.cell.2020.07.022
Contact
- Active Motif on Twitter
- Epigenetics Podcast on Twitter
- Active Motif on Linked-In
- Active Motif on Facebook
- eMail: podcast@activemotif.com
80 에피소드
저장한 시리즈 ("피드 비활성화" status)
When? This feed was archived on September 02, 2022 22:36 (). Last successful fetch was on July 28, 2022 16:40 ()
Why? 피드 비활성화 status. 잠시 서버에 문제가 발생해 팟캐스트를 불러오지 못합니다.
What now? You might be able to find a more up-to-date version using the search function. This series will no longer be checked for updates. If you believe this to be in error, please check if the publisher's feed link below is valid and contact support to request the feed be restored or if you have any other concerns about this.
Manage episode 275046122 series 2369335
In this episode of the Epigenetics Podcast, we caught up with Dr. Oded Rechavi, Professor at the University of Tel Aviv, to talk about his work on the role of small RNAs in transgenerational inheritance in C. elegans.
The most prominent example of transgenerational inheritance is the Dutch famine of 1944 during World War II. Effects of this famine could be observed in the grandchildren of people that lived through this hunger winter, but the molecular mechanisms involved remain largely unknown. The guest of this podcast episode, Dr. Rechavi, has taken on the challenge to unravel parts of this puzzle by studying transgenerational epigenetics in C. elegans.
It was already known that small RNA molecules could play a role in passing on information from one generation to the next, but it was not clear what exactly was being inherited. Was it RNAs? Or chromatin modifications? Or something else?
Dr. Rechavi made several important discoveries in his journey to answer these questions. He started out by showing that RNAi provides an antiviral protection mechanism in C. elegans that can be passed on over multiple generations. He then went on to show that starvation in one generation leads to changes in the lifespan of future generations, and investigate how long this memory could last. Simple dilution of the parental RNA in future generations could not be the answer because the inherited phenotypes lasted much longer than would be possible if this were the case. This led Dr. Rechavi to the discovery that small RNAs were amplified in each generation, and the effect of a stimulus could affect multiple generations. More recently, Dr. Rechavi and his team studied the interplay of neurons and the germ line and how information can be passed on from the brain to the germ line.
In this interview, we cover how Dr. Rechavi chose C. elegans as a model organism, discuss his first major discoveries in the field of transgenerational effects of starvation, and what role epigenetic factors play in this process.
References
- Oded Rechavi, Gregory Minevich, Oliver Hobert (2011) Transgenerational Inheritance of an Acquired Small RNA-Based Antiviral Response in C. elegans (Cell) DOI: 10.1016/j.cell.2011.10.042
- Oded Rechavi, Leah Houri-Ze’evi, … Oliver Hobert (2014) Starvation-induced transgenerational inheritance of small RNAs in C. elegans (Cell) DOI: 10.1016/j.cell.2014.06.020
- Leah Houri-Ze’evi, Yael Korem, … Oded Rechavi (2016) A Tunable Mechanism Determines the Duration of the Transgenerational Small RNA Inheritance in C. elegans (Cell) DOI: 10.1016/j.cell.2016.02.057
- Itamar Lev, Uri Seroussi, … Oded Rechavi (2017) MET-2-Dependent H3K9 Methylation Suppresses Transgenerational Small RNA Inheritance (Current biology: CB) DOI: 10.1016/j.cub.2017.03.008
- Leah Houri-Zeevi, Yael Korem Kohanim, … Oded Rechavi (2020) Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans (Cell) DOI: 10.1016/j.cell.2020.07.022
Contact
- Active Motif on Twitter
- Epigenetics Podcast on Twitter
- Active Motif on Linked-In
- Active Motif on Facebook
- eMail: podcast@activemotif.com
80 에피소드
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