Evaluation and Treatment of Growth Failure in Children


Manage episode 151331845 series 1024365
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Within the last decade, there have been major advances in the understanding of growth hormone deficiency and its impact on stature, especially short stature. Experts suggest that up to 75% of the cases of growth hormone (GH) deficiency may be reversible. Physicians and endocrinologists now recognize that the growth effects of GH are mediated by a substance called insulin-like growth factor 1 (IGF-1). IGF-1, a potent growth and differentiation factor, stimulates the multiple processes leading to statural growth and is normally secreted in response to stimulation by GH.

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