Player FM과 저희 커뮤니티의 Peter Attia, MD, Peter Attia, and MD 콘텐츠는 모두 원 저작자에게 속하며 Player FM이 아닌 작가가 저작권을 갖습니다. 오디오는 해당 서버에서 직접 스트리밍 됩니다. 구독 버튼을 눌러 Player FM에서 업데이트 현황을 확인하세요. 혹은 다른 팟캐스트 앱에서 URL을 불러오세요.

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#229 ‒ Understanding cardiovascular disease risk, cholesterol, and apoB

1:18:54
 
공유
 

Manage episode 345720655 series 2352826
Player FM과 저희 커뮤니티의 Peter Attia, MD, Peter Attia, and MD 콘텐츠는 모두 원 저작자에게 속하며 Player FM이 아닌 작가가 저작권을 갖습니다. 오디오는 해당 서버에서 직접 스트리밍 됩니다. 구독 버튼을 눌러 Player FM에서 업데이트 현황을 확인하세요. 혹은 다른 팟캐스트 앱에서 URL을 불러오세요.

View the Show Notes Page for This Episode

Become a Member to Receive Exclusive Content

Sign Up to Receive Peter’s Weekly Newsletter

In this special episode of The Drive, we have pulled together a variety of clips from previous podcasts about cardiovascular disease to help listeners understand this topic more deeply, as well as to identify previous episodes which may be of interest. In this episode, Peter highlights the importance of understanding cardiovascular disease and why early intervention is critical. He also provides a primer on lipoproteins and explains the fallacy of the terms “good cholesterol” and “bad cholesterol.” Allan Sniderman discusses the metrics measured in routine blood work – along with the limitations of those standard panels – before explaining why apoB is a superior metric for determining risk. Additionally, Tom Dayspring explains the causal role of apoB in atherosclerotic cardiovascular disease (ASCVD) and the therapeutic goals for apoB concentration, and Peter explains how early and aggressive lowering of apoB could change the landscape of cardiovascular disease prevention.

We discuss:

  • The importance of understanding atherosclerosis early in life [2:25]
  • Defining ASCVD, its causes, and the role of cholesterol [8:00];
  • Why early prevention of atherosclerosis is critical [13:45];
  • Preventing atherosclerosis—two fatal flaws with the “10-Year Risk” approach [16:00];
  • Intro to lipids and lipoproteins: why there is no “bad” or “good” cholesterol [23:00];
  • Limitations of standard blood panels [35:45];
  • How Mendelian randomization is bolstering the case for apoB as the superior metric for risk prediction [39:30];
  • Therapeutic goals for apoB concentration [58:15];
  • How early and aggressive lowering of apoB could change the course of ASCVD [1:10:45]; and
  • More.

Connect With Peter on Twitter, Instagram, Facebook and YouTube

  continue reading

301 에피소드

공유
 
Manage episode 345720655 series 2352826
Player FM과 저희 커뮤니티의 Peter Attia, MD, Peter Attia, and MD 콘텐츠는 모두 원 저작자에게 속하며 Player FM이 아닌 작가가 저작권을 갖습니다. 오디오는 해당 서버에서 직접 스트리밍 됩니다. 구독 버튼을 눌러 Player FM에서 업데이트 현황을 확인하세요. 혹은 다른 팟캐스트 앱에서 URL을 불러오세요.

View the Show Notes Page for This Episode

Become a Member to Receive Exclusive Content

Sign Up to Receive Peter’s Weekly Newsletter

In this special episode of The Drive, we have pulled together a variety of clips from previous podcasts about cardiovascular disease to help listeners understand this topic more deeply, as well as to identify previous episodes which may be of interest. In this episode, Peter highlights the importance of understanding cardiovascular disease and why early intervention is critical. He also provides a primer on lipoproteins and explains the fallacy of the terms “good cholesterol” and “bad cholesterol.” Allan Sniderman discusses the metrics measured in routine blood work – along with the limitations of those standard panels – before explaining why apoB is a superior metric for determining risk. Additionally, Tom Dayspring explains the causal role of apoB in atherosclerotic cardiovascular disease (ASCVD) and the therapeutic goals for apoB concentration, and Peter explains how early and aggressive lowering of apoB could change the landscape of cardiovascular disease prevention.

We discuss:

  • The importance of understanding atherosclerosis early in life [2:25]
  • Defining ASCVD, its causes, and the role of cholesterol [8:00];
  • Why early prevention of atherosclerosis is critical [13:45];
  • Preventing atherosclerosis—two fatal flaws with the “10-Year Risk” approach [16:00];
  • Intro to lipids and lipoproteins: why there is no “bad” or “good” cholesterol [23:00];
  • Limitations of standard blood panels [35:45];
  • How Mendelian randomization is bolstering the case for apoB as the superior metric for risk prediction [39:30];
  • Therapeutic goals for apoB concentration [58:15];
  • How early and aggressive lowering of apoB could change the course of ASCVD [1:10:45]; and
  • More.

Connect With Peter on Twitter, Instagram, Facebook and YouTube

  continue reading

301 에피소드

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